Comparing video and direct laryngoscopy for intubating newborns
Official title: A Stepped Wedge Cluster Randomised Trial Of Video Versus Direct Laryngoscopy For Intubation Of Newborn Infants
Run by University College Dublin · NCT06757543 · Data updated 2026-11-12
This study tests whether using video laryngoscopy or direct laryngoscopy is better for helping newborns who need breathing support through intubation.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 0 Minutes to 1 Month |
| Sex | All |
| Enrollment | 840 (estimated) |
| Sponsor | University College Dublin Academic / other |
| Locations | 17 sites (Rijeka and 16 other locations) |
| Status | Recruiting |
| Started | January 13, 2025 |
| Main results expected | August 15, 2026 |
| Study ends | August 31, 2026 |
| Registry record updated | May 4, 2026 |
| Trial ID | NCT06757543 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are newborn infants of any gestational age who require endotracheal intubation.
✕Probably not a fit
Patients whose parents do not consent to the use of their infant's data will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to compare the effectiveness of video laryngoscopy versus direct laryngoscopy for intubating newborn infants who require breathing support. The study will utilize a stepped wedge cluster randomised design, allowing for a systematic evaluation of both techniques across multiple hospitals. By assessing the success rates of intubation attempts and associated complications, the trial seeks to determine which method provides better outcomes for infants in need of intubation. The study will include infants of any gestational age, provided parental consent is obtained for data usage.
Why it matters
Potential benefit: If successful, this study could lead to improved intubation success rates and reduced complications for newborns requiring respiratory support.
How similar studies have gone: Previous studies have shown that video laryngoscopy can improve intubation success rates compared to direct laryngoscopy, indicating potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Infants of any gestational age in whom endotracheal intubation is attempted can be included in this study once there is parental consent to the use their infant's data. Exclusion Criteria: * Infants will be excluded if parents do not consent for their infants' data to be used.
Where it's running
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Clinical Hospital Centre
Rijeka, Croatia Recruiting -
Clinical Hospital "Holy Spirit"
Zagreb, Croatia Recruiting -
University Hospital Brno
Brno, Czechia Recruiting -
General University Hospital
Prague, Czechia Recruiting -
Institute for Mother and Child Care
Prague, Czechia Recruiting -
Aristotle University of Thessaloniki
Thessaloniki, Greece Recruiting
Show 11 more locations
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Second Semmelweiss University
Budapest, Hungary Recruiting -
University of Padova
Padova, Italy Recruiting -
Oslo University Hospital
Oslo, Norway Recruiting -
Medical University of Gdańsk
Gdansk, Poland Recruiting -
Medical University of Silesia
Katowice, Poland Recruiting -
Provincial Hospital No. 2
Rzeszów, Poland Recruiting -
Wrocław Medical University
Wroclaw, Poland Recruiting -
Clinical County Emergency Hospital
Sibiu, Romania Recruiting -
George Emil Palade University
Tărgu Mures, Romania Recruiting -
University and Polytechnic Hospital La Fe
Valencia, Spain Recruiting -
Bukovinian State Medical University
Chernivtsi, Ukraine Recruiting
Study contacts
- Study coordinator: Colm P.F. O'Donnell, MB PhD
- Email: codonnell@nmh.ie
- Phone: +35316373100
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Hyperangulated vs. Macintosh blades for obstetric intubation
This study tests whether a hyperangulated blade or a Macintosh-style blade helps obstetric patients get an endotracheal tube placement more safely during cesarean deliveries under general anesthesia.
-
Comparing oxygen levels and complications with delayed versus rapid sequence intubation
This tests whether delayed sequence intubation or rapid sequence intubation gives better oxygen levels and fewer complications for adults who are breathing on their own but need a breathing tube for non‑traumatic reasons.
-
Effect of a brief educational intervention on endotracheal tube cuff pressure
A short educational video and reminder posters are tested to see if they help operating room staff keep endotracheal tube cuff pressure within the recommended range for adult patients under general anesthesia.
-
Two Videolaryngoscopes for Intubating Children: A Pediatric Comparison
This observational study tests how two different videolaryngoscopes perform during pediatric intubations to see which makes the process quicker and easier.
-
Predicting difficult mask ventilation and intubation using STOP-BANG in obese adults
This study will test whether the STOP-BANG questionnaire can predict difficult mask ventilation and difficult intubation in obese adults having elective surgery.
-
Paternal gentle touch to improve newborn feeding, comfort, and blood sugar
This will try gentle hand touch by fathers during the first six hours to see if it improves sucking, comfort, and blood glucose in newborns at risk for low blood sugar.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.