Comparing ventilation strategies for protecting the right ventricle in ARDS

Transpulmonary Pressure Guided Mechanical Ventilation Strategy for Right Ventricle Protection in Acute Respiratory Distress Syndrome

This study is testing a new way of using mechanical ventilation to see if it better protects the heart's right ventricle in people with Acute Respiratory Distress Syndrome compared to the usual method.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 40 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Beijing Chao Yang Hospital (Academic / other)
• Locations: 1 site (Beijing, Beijing)
• Trial ID: NCT05629832 on ClinicalTrials.gov

What this trial studies

This study aims to compare the effectiveness of a mechanical ventilation strategy guided by transpulmonary pressure against a traditional lung protective ventilation strategy in patients with Acute Respiratory Distress Syndrome (ARDS). The focus is on protecting the right ventricle during mechanical ventilation. Eligible participants must have been on invasive mechanical ventilation for less than 72 hours and meet the Berlin definition for ARDS. The study will assess outcomes related to right ventricular function and overall respiratory health.

Who should consider this trial

Good fit: Ideal candidates are adults over 18 who have been on invasive mechanical ventilation for less than 72 hours and meet the diagnostic criteria for ARDS.

Not a fit: Patients with certain conditions such as severe bronchopleural fistula, tricuspid stenosis, or those who have undergone esophageal or cardiac surgery may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could lead to improved outcomes for patients with ARDS by better protecting heart function during mechanical ventilation.

How similar studies have performed: While there is ongoing research in mechanical ventilation strategies, this specific approach focusing on transpulmonary pressure in ARDS is relatively novel and has not been extensively tested.

Eligibility criteria

Inclusion Criteria:

* duration of invasive mechanical ventilation less than 72 hours;
* meet the diagnostic criteria of Berlin definition for ARDS;
* age older than 18

Exclusion Criteria:

* esophageal surgery or damage;
* cardiac surgery;
* severe bronchopleural fistula;
* serious arrhythmia; pneumothorax;
* tricuspid stenosis;
* heparin allergy;
* chronic pulmonary heart disease

Where this trial is running

Beijing, Beijing

• Beijing Chao-Yang Hospital — Beijing, Beijing, China (Recruiting)

Study contacts

• Study coordinator: Xiao Tang, MD

Conditions Acute Respiratory Distress Syndrome; Acute Cor Pulmonale