Comparing utidelone and docetaxel for advanced breast cancer

Utidelone Versus Docetaxel in HER2-negative Locally Advanced or Metastatic Breast Cancer : A Phase III, Open Label, Randomized Controlled Trial

This study is testing whether a new drug called utidelone works better than docetaxel for women with advanced breast cancer that is HER2-negative.

Quick facts

• Phase: Phase 3
• Study type: Interventional
• Enrollment: 349 (estimated)
• Ages: 18 Years and up
• Sex: Female
• Sponsor: Sun Yat-sen University (Academic / other)
• Drugs / interventions: chemotherapy, immunotherapy
• Locations: 2 sites (Guangzhou, Gangdong and 1 other locations)
• Trial ID: NCT05430399 on ClinicalTrials.gov

What this trial studies

This phase III trial investigates the efficacy and safety of utidelone compared to docetaxel in women with HER2-negative locally advanced or metastatic breast cancer. Participants must have documented breast cancer and meet specific criteria regarding previous treatments and disease status. The study aims to determine which treatment provides better outcomes for patients with this type of cancer.

Who should consider this trial

Good fit: Ideal candidates are women aged 18 and older with HER2-negative locally advanced or metastatic breast cancer who have not received prior chemotherapy for advanced disease.

Not a fit: Patients with HER2-positive breast cancer or those who have previously received chemotherapy for advanced breast cancer may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could offer a more effective treatment option for patients with HER2-negative locally advanced or metastatic breast cancer.

How similar studies have performed: Other studies have explored similar treatment comparisons in breast cancer, but the specific use of utidelone in this context is relatively novel.

Eligibility criteria

Inclusion Criteria:

* Signed the informed consent form;
* Women aged ≥ 18 years;
* Patients with locally advanced or metastatic, histologically or cytologically documented breast cancer;
* The primary tumor and metastases (if re-biopsy was performed) were both HER2-negative;
* Eastern Cooperative Oncology Group (ECOG) score \[0-1\] points;
* Patients must have metastatic disease that is evaluable on imaging: including at least one measurable lesion (assessed according to Response Evaluation Criteria in Solid Tumors (RECIST 1.1)); or only non-measurable disease as defined by RECIST 1.1 , especially in patients with bone metastases only, while the disease could be documented/assessed by bone scan, PET or MRI;
* Previous chemotherapy with taxane for early breast cancer (eBC; neoadjuvant or adjuvant setting) is permitted if completed ≥12 months before randomization;
* No previous chemotherapy for advanced breast cancer ;
* For HR+ breast cancer patients shall meet one of the two criteria below: a) radiographically confirmed recurrence or progression within 2 years of adjuvant endocrine therapy; b) received at least one line of endocrine therapy in the recurrence or metastasis stage;
* Patients must have recovered to ≤ Grade 1 (CTCAE v5.0) from all toxicities related to prior antineoplastic therapy. However, patients with any grade of alopecia were allowed ;
* Patients with asymptomatic CNS metastases may be enrolled, if:

  1. Intracranial lesions are evaluable and eligible for systemic therapy only in the absence of extracranial evaluable lesions, or
  2. Patients with stable intracranial lesions after local treatment while there are extracranial evaluable lesions ;
* Adequate hematological, hepatic and renal function;
* Women of childbearing potential must agree to use a contraceptive method during the treatment period and for at least 90 days after the last dose of experiment treatment;
* Life expectancy of at least 12 weeks;
* Patients must be able to participate and comply with treatment and follow up.

Exclusion Criteria:

* HER-2 positive (IHC 3+, or FISH positive);
* Other malignancies (including primary brain or leptomeninges-related tumors) within the past 5 years, except cured cutaneous basal cell carcinoma and cervical carcinoma in situ;
* Patients who have received anti-tumor therapy within 4 weeks prior to the start of study treatment, including chemotherapy, radical radiotherapy, biological therapy, immunotherapy or anti-tumor Chinese medicine therapy;
* Patients who have undergone major organ surgery (excluding needle biopsy) or have significant trauma within 4 weeks before the first dose of treatment, or anticipating for a major surgical procedure during the study;
* Experienced grade ≥ 3 nervous system-related adverse events after treatment with anti-microtubule drugs;
* Symptomatic central nervous system metastases;
* Pregnant or lactating women;
* Known or suspected hypersensitivity to any of the study drugs or excipients;
* Any other non-malignant systemic disease (cardiovascular, renal, hepatic, etc.) that precludes study treatment implementation or follow-up ;
* Any other condition that the investigator considers inappropriate to participate in this trial .
* Use of corticosteroids is prohibited.

Where this trial is running

Guangzhou, Gangdong and 1 other locations

• Shusen Wang — Guangzhou, Gangdong, China (Recruiting)
• Hunan Cancer Hospital — Hunan, Hunan, China (Not_yet_recruiting)

Study contacts

• Study coordinator: shusen wang, MD

Conditions Breast Neoplasms; Locally Advanced or Metastatic Breast Cancer