Comparing ultrasound and CT for monitoring Crohn's disease
Correlation and Assessment of Small Bowel Lesion Using Cross Sectional Imaging Techniques Compared to Small Intestinal Contrast Ultrasonography in Known Small Bowel Crohn's Disease(the CACTUS-CD Trial): a Prospective Study
This study is testing if a new ultrasound method can better monitor Crohn's disease in patients compared to traditional imaging techniques like CT scans.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | Asian Institute of Gastroenterology, India Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Hyderabad, Telangana) |
| Trial ID | NCT06125678 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of small intestinal contrast ultrasound (SICUS) compared to traditional imaging methods like computed tomography enteroclysis (CTE) and magnetic resonance enterography (MRE) in patients with Crohn's disease. Participants will ingest polyethylene glycol to enhance imaging without radiation exposure, while also undergoing CTE for comparison. The study aims to determine the accuracy and patient comfort of SICUS in monitoring disease status and treatment response. Experienced operators will conduct all imaging procedures to ensure consistency and reliability of results.
Who should consider this trial
Good fit: Ideal candidates include patients with known small bowel Crohn's disease who require monitoring due to therapy assessment or new symptoms.
Not a fit: Patients who are obese with poor ultrasound windows, pregnant or lactating, or those with renal insufficiency may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a safer, radiation-free imaging option for patients with Crohn's disease.
How similar studies have performed: While traditional imaging methods have been well-studied, the use of SICUS as a primary monitoring tool in Crohn's disease is relatively novel and less explored.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with known small bowel CD beyond reach of standard endoscopy who warrants monitoring of disease status either due to assessment of response to therapy/relapse/new unexplained symptoms, persistent disease activity, prior to switching therapy or deciding on surgical management. Exclusion Criteria: * Obese patients with poor ultrasound window * pregnant/lactating mother * Not willing for CT or enteroclysis examination * Renal insufficiency precluding CT
Where this trial is running
Hyderabad, Telangana
- Asian Institute of Gastroenterology — Hyderabad, Telangana, India (Recruiting)
Study contacts
- Principal investigator: Partha Pal, MD, DrNB — Asian Institute of Gastroenterology and Asian Healthcare Foundation
- Study coordinator: Partha Pal, MD, DrNB
- Email: partha1986@yahoo.com
- Phone: +91-8945906823
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.