Comparing Ultra High-Resolution CT to Conventional CT for Heart Disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of Ultra High-Resolution Computed Tomography (UHR-CT) compared to conventional CT in identifying obstructive coronary heart disease (CHD) in a lower-risk population. Participants will undergo a single scan using UHR-CT, which allows for the reconstruction of conventional resolution images from the same data, minimizing radiation exposure and scan time. The primary goal is to gather preliminary data to support the hypothesis that UHR-CT is superior in detecting CHD. This approach aims to justify the broader implementation of UHR-CT technology in clinical practice.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged 21-85 years
* Clinical history suggestive of CHD who are referred by their primary cardiologist for further evaluation via Computed tomography angiography (CTA) will be asked to participate.
* Women of child bearing potential must demonstrate a negative pregnancy test within 24 hours of the study CTA.
* Ability to understand and willingness to sign the Informed Consent Form.

Exclusion Criteria:

* Known allergy to iodinated contrast media.
* History of multiple myeloma or previous organ transplantation
* Elevated serum creatinine (\> 1.5mg/dl) OR calculated creatinine clearance of \< 60 ml/min (using the Cockcroft-Gault formula
* Atrial fibrillation or uncontrolled tachyarrhythmia, or advanced atrioventricular block (second or third degree heart block)
* Evidence of severe symptomatic heart failure (NYHA Class III or IV);
* Known or suspected moderate or severe aortic stenosis
* History of prior percutaneous coronary intervention (PCI) in one or more vessel or history of coronary arterial bypass grafting (CABG)
* Suspected acute coronary syndrome
* Presence of any other history or condition that the investigator feels would be problematic

Where it's running

• Johns Hopkins School of Medicine
  Baltimore, Maryland, United States Recruiting

Study contacts

• Principal investigator: Joao Lima, Professor — Md
• Study coordinator: Joao Lima, Professor
• Email: jlima@jhmi.edu
• Phone: 4106141284

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.