Comparing two treatments for wet age-related macular degeneration

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of two different treatments for neovascular age-related macular degeneration (AMD): intravitreal injections of bevacizumab (Avastin) and aflibercept (Eylea). It aims to determine if patients receiving bevacizumab after two years require more injections while maintaining therapy response compared to those treated with aflibercept. Additionally, the study evaluates differences in visual acuity, macular thickness, recurrence intervals, treatment durability, cost efficiency, and quality of life related to vision. The findings could provide insights into the most effective long-term treatment options for AMD.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Signed informed consent.

≥50 years, regardless of gender.

Diagnosed with the neovascular (wet) form of age-related macular degeneration through diagnosed neovascular vascular membranes with OCT-A and, if necessary, also FA / ICG, according to clinical routine.

Distance visual acuity ≥34 (ETDRS) on the current study eye.

Exclusion Criteria:

Other eye disease in the current study eye that affects visual acuity or the possibility of examining fundus, according to the investigator's assessment.

Previously received treatment for the neovascular (wet) form of age-related macular degeneration.

Diagnosed with diabetes (all types).

Degenerative state of the macula that prevents vision improvement such as central areolar atrophy or other pronounced dry AMD or fibrosis, in the current study eye.

Other choroidal neovascularization (CNV) of the type PCV or due to grave myopia i.e. ≥ 6.0 diopters (D) or secondary to other retinal disease, in the current study eye.

Unregulated intraocular pressure (IOP) \> 30 mmHg despite pharmacological treatment in the current study eye.

Have had a stroke or heart attack ≤6 months ago.

Inability to access information (e.g. due to dementia) or inability to conduct examinations (e.g. ETDRS examination), according to the investigator's assessment.

Inability to receive oral and written information in Swedish (in need of an interpreter).

Included in another intervention study.

Fertile woman i.e. a woman who has had menstruation for the past 12 months or has not undergone permanent sterilization (hysterectomy, bilateral salpingectomy or bilateral oophorectomy).

Where it's running

• Vastra Gotaland Region, Sahlgrenska University Hospital, Department of Ophthalmology
  Mölndal, Sweden Recruiting

Study contacts

• Principal investigator: Madeleine Zetterberg, MD, PhD — Vastra Gotaland Region
• Study coordinator: Madeleine Zetteberg, MD, PhD
• Email: madeleine.zetterberg@vgregion.se
• Phone: +46 (0)31-3433255

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.