Comparing two treatments for benign prostatic hyperplasia
Official title: A Prospective, Single-center, Randomized Controlled Trial Comparing the Efficacy and Safety of High Freqnence Irreversible Electroporation and Trans Urethral Resection Prostate for Benign Prostatic Hyperplasia
Run by Shanghai East Hospital · NCT05306145 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing whether a new treatment using high-frequency electroporation works better than the standard surgery for men with enlarged prostates to see which one helps improve their urinary flow and symptoms.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 40 Years and up |
| Sex | Men only |
| Enrollment | 118 (estimated) |
| Sponsor | Shanghai East Hospital Academic / other |
| Locations | 1 site (Shanghai) |
| Trial ID | NCT05306145 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are men over 40 years old with moderate to severe urinary symptoms and specific prostate volume measurements.
✕Probably not a fit
Patients with a history of prostate cancer or those with certain urinary tract conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial compares the efficacy and safety of high-frequency irreversible electroporation with transurethral resection of the prostate in men suffering from benign prostatic hyperplasia. A total of 176 patients will be randomly assigned to one of the two treatment arms. The primary outcomes will focus on changes in maximum urinary flow rate and urinary symptoms, assessed using the International Prostate Symptom Score at three months post-treatment. The study aims to provide insights into which treatment may offer better results for patients.
Why it matters
Potential benefit: If successful, this study could provide a more effective treatment option for men with benign prostatic hyperplasia.
How similar studies have gone: While there have been studies on both treatments, this specific comparison of high-frequency irreversible electroporation against transurethral resection is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age over 40 years old 2. IPSS\>8 3. Qmax \<15ml/s 4. Prostatic volume range of 30 to 100ml, measured by MRI 5. Fully understand the clinical trial protocol and sign the informed consent Exclusion Criteria: Have a history of prostate cancer or patients suspicious of prostate cancer Neurogenic bladder Metal implants in their body Previous history of prostatic or urethral surgery With Catheterisation more than 2 weeks Any other conditions that investigator judges that participations who are not suitable for this trial
Where it's running
-
Haifeng Wang
Shanghai, China Recruiting
Study contacts
- Principal investigator: Haifeng Wang — Shanghai East Hospital,Tongji University School of Medicine
- Study coordinator: Biming He
- Email: 190589109@qq.com
- Phone: +8615502139410
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Sonablate HIFU Registry for Prostate Cancer and BPH
This registry collects real-world data from men treated with Sonablate HIFU to see how well it works and how it affects urinary and sexual function over the long term.
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Tamsulosin alone vs. tamsulosin with tadalafil for troublesome urinary symptoms from enlarged prostate
This study tests whether adding tadalafil to tamsulosin helps men with BPH see better urinary symptoms and quality of life, using two tadalafil doses over 12 weeks.
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MRI-DTI look at the urethral sphincter ring and prostate base shape
This imaging study tests how the male urethral internal sphincter ring appears on MRI-DTI and how it relates to prostate base morphology in men undergoing clinically indicated MRI.
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Tamsulosin With or Without Tadalafil for a Trial Without Catheter After Acute Urinary Retention
This study tests whether adding tadalafil to tamsulosin helps men with a first episode of acute urinary retention due to enlarged prostate pass urine without needing a catheter.
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Tamsulosin dose change or switch to silodosin before catheter removal in men with BPH-related acute urinary retention
This trial tests whether continuing tamsulosin, increasing its dose, or switching to silodosin helps men with BPH-related acute urinary retention go without a catheter after seven days.
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Water Vapor Therapy vs Ejaculation-Sparing Enucleation for Benign Prostatic Hyperplasia
This study tests whether Water Vapor Thermal Therapy (Rezum) or an ejaculation-sparing enucleation procedure better helps sexually active men with bothersome BPH symptoms.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.