Comparing two sedation medications in ICU patients with low blood pressure

Comparing Ciprofol and Propofol for Sedation in Hypotensive ICU Patients: a Single Center Prospective Cohort Study

This study is testing whether ciprofol or propofol works better for sedating ICU patients with low blood pressure who need extra support to keep their blood pressure up.

Quick facts

• Study type: Observational
• Enrollment: 456 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Nanfang Hospital, Southern Medical University (Academic / other)
• Locations: 1 site (Guangzhou)
• Trial ID: NCT05971121 on ClinicalTrials.gov

What this trial studies

This observational cohort study aims to compare the effectiveness of ciprofol and propofol for sedation in ICU patients who are hypotensive and require vasopressor support. Over a two-year period, 456 patients will be enrolled based on their sedation needs and the medication prescribed by their healthcare providers. Participants will be divided into two groups based on whether they receive ciprofol or propofol, and data will be collected from their routine clinical records to assess outcomes.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older who require sedation and vasopressors to maintain adequate blood pressure in the ICU.

Not a fit: Patients who are pregnant, have severe neurological conditions, or have allergies to the study medications will not benefit from this study.

Why it matters

Potential benefit: If successful, this study could identify the more effective sedation option for hypotensive ICU patients, potentially improving their comfort and safety.

How similar studies have performed: While there have been studies comparing sedation methods, this specific comparison of ciprofol and propofol in hypotensive patients is novel.

Eligibility criteria

Inclusion Criteria:

* Age ≥ 18;
* It needs to be treated with vasopressors to maintain mean arterial pressure ≥65 mmHg;
* Sedative medication required for comfort, safety, and to facilitate life support measures;
* Obtain the informed consent of the human subjects or their legal representatives.

Exclusion Criteria:

* Pregnant patient;
* Patients with proven acute severe intracranial or spinal neurological disease due to vascular, intracranial dilatation, or injury;
* History of allergy to cyclopofol, propofol, eggs, or soy products;
* History of long-term use of benzodiazepines or opioids;
* Sedative drugs other than propofol or cyclopofol were used at enrollment, or propofol and cyclopofol were used alternately within 24 hours;
* The researchers judged that they are not suitable to participate in this study.

Where this trial is running

Guangzhou

• Southern medical university Nanfang hospital — Guangzhou, China (Recruiting)

Study contacts

• Study coordinator: Zengzhu He, master

Conditions Ciprofol; Propofol; Sedation; Low Blood Pressure; Norepinephrine