Comparing two root canal sealers for pain relief after dental procedures
Official title: A COMPARATIVE EVALUATION OF POST-OPERATIVE PAIN AFTER ROOT CANAL THERAPY USING TWO DIFFERENT ENDODONTIC SEALERS IN PATIENTS WITH SYMPTOMATIC IRREVERSIBLE PULPITIS
Run by Armed Forces Institute of Dentistry, Pakistan · NCT06975761 · Data updated 2026-11-12
This study is testing which of two root canal sealers helps young men with severe tooth pain feel better after their dental treatment.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Ages | 20 Years to 40 Years |
| Sex | All |
| Enrollment | 62 (estimated) |
| Sponsor | Armed Forces Institute of Dentistry, Pakistan Academic / other |
| Locations | 1 site (Rawalpindi, Punjab Province) |
| Status | Recruiting |
| Started | April 7, 2025 |
| Main results expected | August 7, 2025 |
| Study ends | August 7, 2025 |
| Registry record updated | May 16, 2025 |
| Trial ID | NCT06975761 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are healthy male patients aged 20-40 with irreversible pulpitis in permanent mandibular first molars.
✕Probably not a fit
Patients with calcified canals, previously treated teeth, or those with reversible pulpitis will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to compare the effectiveness of two different root canal sealers in reducing postoperative pain in patients with irreversible pulpitis. A total of 62 male patients aged 20-40 will be randomly assigned to receive either a resin-based sealer or a zinc oxide eugenol-based sealer during their root canal therapy. The study will involve thorough screening, including medical history and radiographs, and will be conducted under local anesthesia with strict adherence to infection control protocols. The outcomes will be assessed to determine which sealer provides better pain management post-treatment.
Why it matters
Potential benefit: If successful, this study could lead to improved pain management strategies for patients undergoing root canal therapy.
How similar studies have gone: Previous studies have shown varying success with different root canal sealers, but this specific comparison is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Permanent mandibular first molar with irreversible pulpitis without swelling and sinus. 2. Patients of male gender between 20-40 years of age. 3. Systemically healthy patients with no other co morbidity classified as ASA-I 4. Patients who agree to attend for re call appointments and provide a written consent Exclusion Criteria: \- 1. Teeth with calcified canals and previously treated teeth. 2. Mandibular molars with reversible pulpitis. 3. Pregnant and lactating mothers. 4. Patients who are immunocompromised, anxious, mentally ill. 5. Cases of root fracture. 6. Patients who consumed analgesics 12-24 hrs before primary root canal therapy. 7\. Patients who are allergic to any of the medications being tested.
Where it's running
-
Armed Forces Institute of Dentistry
Rawalpindi, Punjab Province, Pakistan Recruiting
Study contacts
- Principal investigator: Areeba Maryam, BDS — Afid
- Study coordinator: Areeba Maryam, BDS
- Email: areebamaryam94@yahoo.com
- Phone: +923344782776
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.