Comparing two pain relief methods for hip surgery

Comparison Between Bupivacaine-Dexmedetomidine Versus Bupivacaine-Dexamethasone in Pericapsular Nerve Group (PENG) Block as Post-operative Analgesia in Hip Surgeries.

This study is testing two different pain relief mixtures for hip surgery to see which one helps patients feel better after their operation.

Quick facts

• Phase: PHASE1
• Study type: Interventional
• Enrollment: 60 (estimated)
• Ages: 18 Years to 65 Years
• Sex: All
• Sponsor: Ain Shams University (other)
• Locations: 1 site (Cairo)
• Trial ID: NCT06294665 on ClinicalTrials.gov

What this trial studies

This study aims to compare the effectiveness of two mixtures, bupivacaine-dexmedetomidine and bupivacaine-dexamethasone, in providing post-operative analgesia through the Pericapsular Nerve Group (PENG) block for patients undergoing hip surgeries. It involves administering these mixtures to patients scheduled for hip surgeries under spinal anesthesia and assessing their pain relief outcomes. The study is designed as a Phase 1 interventional trial to evaluate the safety and efficacy of these treatments.

Who should consider this trial

Good fit: Ideal candidates for this study are adults aged 18-65 years scheduled for hip surgeries under spinal anesthesia with ASA Physical Status Class I and II.

Not a fit: Patients with ASA Physical Status Class III and IV, those with contraindications to regional anesthesia, or those who decline to give informed consent may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide a more effective pain management option for patients undergoing hip surgeries.

How similar studies have performed: While this specific comparison is novel, similar studies have shown promising results in using nerve blocks for post-operative pain management.

Eligibility criteria

Inclusion Criteria:

1. Age 18-65 years.
2. Sex: Both sexes.
3. American Society of Anaesthesiologists (ASA) Physical Status Class I and II.
4. Scheduled for hip surgeries under spinal anaesthesia.

Exclusion Criteria:

1. Declining to give written informed consent.
2. History of allergy to the medications used in the study.
3. Contraindications to regional anesthesia (including patient refusal, coagulopathy and local infection).
4. Psychiatric disorder.
5. American Society of Anesthesiologists (ASA) Physical Status Class III and IV.

Where this trial is running

Cairo

• Ain Shams University — Cairo, Egypt (RECRUITING)

Study contacts

• Study coordinator: Mohamed AA Salama

Conditions: Hip Fractures, Post Operative Pain