Comparing two methods to predict ovulation outcomes in women with PCOS

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of two different homeostatic model assessments for insulin resistance (HOMA1-IR and HOMA2-IR) in predicting ovulation outcomes in women diagnosed with Polycystic Ovarian Syndrome (PCOS) who are seeking fertility treatment. A total of 122 participants will undergo insulin resistance assessments and will be treated with the aromatase inhibitor Letrozole to induce ovulation. Ultrasound monitoring will track follicular growth until the dominant follicle reaches the appropriate size for ovulation. The study aims to determine which assessment method provides better predictive outcomes for ovulation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18-35 years
* duration of infertility 1-4 years
* PCOS

Exclusion Criteria:

women with other causes of infertility (tubal factor assessed by laparoscopy or hysterosalpingogram, uterine cavity abnormality assessed by ultrasound or hysteroscopy or male factor assessed by seme analysis),

* endometriosis,
* ovarian cysts,
* endocrinological abnormalities (Diabetes mellitus, hypothalamic, pituitary or thyroid disorders, or hyperprolactinemia),
* women with history of poor ovarian response or ovarian hyperstimulation
* women with chronic diseases, chromosomal, autoimmune or coagulation defects, abnormal leucocytic count or other inflammatory markers
* Women with contraindications to pregnancy.

Where it's running

• Kasr Alainy medical school
  Cairo, Egypt Recruiting

Study contacts

• Principal investigator: Ahmed Maged, MD — Cairo University
• Study coordinator: Ahmed Maged, MD
• Email: dr_ahmedmaged08@kasralainy.edu.eg
• Phone: 01005227404

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Evaluating biomarkers for diagnosing PCOS in young women

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.