Comparing two methods of nerve block for foot and ankle surgery

How Do We Ultrasound-Guided Popliteal Approach Sciatic Nerve Block;Is It Injection Subparaneural, Interneural?

Not applicable Interventional Ankara City Hospital Bilkent · NCT06372691

This study is testing which of two injection techniques for nerve blocks works better for pain relief in adults having foot, ankle, or toe surgery.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment809 (estimated)
Ages18 Years and up
SexAll
SponsorAnkara City Hospital Bilkent Academic / other
Locations1 site (Ankara, Çankaya)
Trial IDNCT06372691 on ClinicalTrials.gov

What this trial studies

This prospective, randomized, observer-blind study aims to compare the effectiveness of two injection techniques—subparaneural and interneural—in performing popliteal sciatic nerve blocks for patients undergoing foot, ankle, or toe amputation. Participants will be ASA III or IV risk group adults aged 18 and older. The study will assess sensory and motor blockage at regular intervals following local anesthetic injection, documenting various block characteristics and any complications that arise. The goal is to determine which method provides better anesthesia outcomes.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older with ASA III or IV status who are scheduled for foot, ankle, or toe amputation.

Not a fit: Patients with neurological or psychiatric diseases, chronic pain requiring opioids, or those allergic to local anesthetics may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved pain management and reduced complications for patients undergoing foot and ankle surgeries.

How similar studies have performed: Other studies have shown varying success with similar nerve block techniques, but this specific comparison is novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* 18 years and over
* Planned foot, ankle or toe amputation
* ASA III-IV risk group
* Patients who agreed to be included in the study

Exclusion Criteria:

* People with neurological and psychiatric diseases
* Using opioids or another analgesic for chronic pain
* Allergic to local anesthetics
* Pregnant or breastfeeding
* Those with infection or sepsis in the application area
* Patients who did not agree to be included in the study

Where this trial is running

Ankara, Çankaya

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions AdultRegional Anesthesia MorbidityAnesthesia Injection SitePopliteal Approach Sciatic Nerve BlockRegional AnesthesiaFoot, Ankle and Toe Amputation
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.