Comparing two methods for weaning patients off mechanical ventilation
Mechanical Ventilator Weaning in Chronically Ventilated Patients
NA · University of California, Los Angeles · NCT06976554
This study is testing two different methods to help patients on mechanical ventilation breathe on their own again, to see which one works better for people needing long-term support.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 300 (estimated) |
| Sex | All |
| Sponsor | University of California, Los Angeles (other) |
| Locations | 1 site (Los Angeles, California) |
| Trial ID | NCT06976554 on ClinicalTrials.gov |
What this trial studies
This study evaluates two different strategies for weaning patients from mechanical ventilation: Pressure Support Ventilation (PSV) and Therapist implemented Patient Specific weaning (TIPS). PSV involves a faster approach with 12 hours of weaning followed by 12 hours of rest on the ventilator, aiming for weaning within 2 weeks. In contrast, TIPS gradually reduces support over a 3-week period. Patients requiring prolonged mechanical ventilation and admitted to Barlow Respiratory Hospital will be enrolled within 72 hours of admission to assess the effectiveness of these strategies.
Who should consider this trial
Good fit: Ideal candidates are patients requiring positive pressure mechanical ventilation for at least 21 days and who have a secure tracheostomy.
Not a fit: Patients who are unable to provide informed consent or have a life expectancy of less than 3 months may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve the weaning process from mechanical ventilation, potentially reducing hospital stays and improving patient outcomes.
How similar studies have performed: Other studies have explored ventilator weaning strategies, but this specific comparison of PSV and TIPS is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients requiring positive pressure mechanical ventilation for at least 21 days prior to BRH admission and 2. Have a secure tracheostomy. Exclusion Criteria: 1. Inability to obtain informed consent from patient or DPOA 2. Incarcerated patients 3. Patients with less than 3 months of life expectancy 4. Patients requiring vasopressor medication to stabilize blood pressure on admission 5. Systolic blood pressure less than 90mmHg on admission 6. Pulse less than 50 or greater than 130 beats per minute or change by more than 20 from baseline on admission 7. Respiratory rate greater than 35/min 8. Oxygen saturation less than 90% 9. PEEP\>5cmH2O 10. Lung tidal volume less than 250ml despite MV support 11. At least one previous admission to BRH with unsuccessful ventilator liberation attempt 12. Length of Stay (LOS) at BRH less than 24hours 13. Patients pass spontaneous breathing trial (SBT) on D1 and eligible for cool aerosol, except if they fail SBT on D2 and require continued MV
Where this trial is running
Los Angeles, California
- Barlow Respiratory Hospital — Los Angeles, California, United States (RECRUITING)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Mechanical Ventilation Complication, prolonged mechanical ventilation, ventilator weaning, tracheostomy