Comparing two methods for pain relief after abdominal surgery
Ultrasound Guided Rectus Sheath Block Versus Intrathecal Morphine for Postoperative Analgesia in Patients Undergoing Open Total Abdominal Hysterectomy: A Randomized Trial
This study is testing whether a special pain relief shot in the abdomen works better than morphine given in the spine for people recovering from abdominal surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | Female |
| Sponsor | Ain Shams University Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06837506 on ClinicalTrials.gov |
What this trial studies
This study compares the effectiveness and safety of ultrasound-guided rectus sheath block and intrathecal morphine for providing pain relief after open total abdominal hysterectomy. The rectus sheath block involves injecting a local anesthetic into the rectus sheath to block sensory nerves, while intrathecal morphine delivers medication directly into the cerebrospinal fluid for pain management. The goal is to determine which method offers better postoperative analgesia and enhances recovery for patients undergoing this major surgery.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 65 who are undergoing open total abdominal hysterectomy and are classified as ASA physical status I or II.
Not a fit: Patients with hepatic, renal, or cardiac diseases, or those with allergies to local anesthetics may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved pain management strategies for patients recovering from major abdominal surgery.
How similar studies have performed: Previous studies have shown promising results for both rectus sheath blocks and intrathecal morphine in postoperative pain management, indicating that this approach is supported by existing evidence.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age: 18 - 65 years old. * American Society of Anesthesiologists (ASA) physical status (I -II). * Patients undergoing open total abdominal hysterectomy. Exclusion Criteria: * Hepatic, renal, or cardiac disease. * Any known allergy to local anesthetic. * Physical or mental conditions which may vague measuring postoperative pain following surgery. * History of chronic use of analgesic as nonsteroidal anti-inflammatory drugs (NSAIDs) or central nervous system (CNS) depressants as antiepileptic, and bleeding disorders.
Where this trial is running
Cairo
- Ain Shams University — Cairo, Egypt (Recruiting)
Study contacts
- Study coordinator: Sarah A Afifi, MD
- Email: Sarah606060@gmail.com
- Phone: 0501035864
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.