Comparing two levels of CPAP for preterm infants in the delivery room

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot clinical trial investigates the effects of two different levels of continuous positive airway pressure (CPAP) on preterm infants with respiratory distress syndrome (RDS) at birth. The study compares the efficacy and safety of administering CPAP at 5 cmH2O versus 8 cmH2O during the first 15 minutes of life to determine which level better promotes lung recruitment. The trial aims to assess short-term respiratory outcomes and the potential long-term benefits of improved lung function in these vulnerable infants. Participants will include preterm infants born between 26 and 29+6 weeks gestational age requiring noninvasive respiratory support.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Preterm infants at birth between 26 and 29+6 weeks gestational age with Respiratory distress syndrome requiring non invasive respiratory support

Exclusion Criteria:

* Congenital anomalies

Where it's running

• Ospedale dei Bambini Vittore Buzzi
  Milano, Lombardy, Italy Recruiting

Study contacts

• Study coordinator: Francesco Cavigioli, MD
• Email: francesco.cavigioli@asst-fbf-sacco.it
• Phone: +39263635341

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Surfactant delivery methods in preterm infants with RDS in Sweden

  This study tests different ways of giving surfactant to preterm babies with respiratory distress to see which method works best when care is routine.

  Recruiting Vastra Gotaland Region · Gothenburg · NCT07550218

• Lung ultrasound score to guide surfactant timing in preterm newborns

  This study tests whether using a lung ultrasound score can speed up diagnosing severe RDS and getting surfactant to moderately and late-preterm babies in the NICU.

  Recruiting Hackensack Meridian Health · Hackensack, New Jersey · NCT07442669

• Predicting which newborns in a lower-level NICU will need extended breathing support

  This project will test whether analyzing a newborn's stomach fluid right after birth can help predict which babies born at 32+ weeks and attended by the neonatal resuscitation team will need breathing support for more than six hours.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07344714

• Optimising breathing support at extubation for very preterm infants

  This trial will try starting nasal CPAP before removing the breathing tube versus starting it after extubation to see if that reduces oxygen drops in very preterm infants.

  Recruiting at 3 sites Murdoch Childrens Research Institute · Melbourne, Victoria and 2 other locations · NCT07251790

• Surfactant given through a laryngeal mask for preterm babies with RDS in Vietnam

  For preterm babies under 34 weeks with respiratory distress, the team will try giving surfactant through a soft throat mask (SALSA) instead of an endotracheal tube (INSURE) to see if it reduces the need for invasive breathing support.

  Recruiting Karolinska Institutet · Hanoi · NCT07098910

• Giving surfactant to premature infants using a thin catheter at birth

  This study is testing if giving a special lung treatment to very premature babies right after birth using a thin tube can help them breathe better and need less breathing support in their first few days of life.

  Recruiting University College Dublin · Dublin, None Selected · NCT06557551

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.