Comparing two endoscopic techniques for detecting cancer in ulcerative colitis patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to compare the effectiveness of chromoendoscopy and virtual chromoendoscopy techniques in detecting neoplasia in patients with longstanding ulcerative colitis. Patients enrolled in this study will undergo surveillance endoscopies to evaluate the performance of these imaging methods against the current standard of care, which involves random biopsies. The study seeks to determine if chromoendoscopy, which uses contrast agents, can reduce the number of biopsies needed while improving the detection of cancerous lesions. The findings could lead to more efficient and cost-effective surveillance protocols for patients at risk of colon cancer due to ulcerative colitis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with longstanding ulcerative colitis ( 8 years after diagnosis or pancolitis and 10 years after diagnosis of left-sided colitis)
* Signed informed consent form
* Previous surveillance endoscopy \> 1 year

Exclusion Criteria:

* Active ulcerative colitis, \> 20 cm from the margo ani
* Personal history of colorectal cancer
* Allergy or intolerance to methylene blue
* Refusing or incapable to agree with informed consent
* Age younger than 18 years
* Pregnant women

Where it's running

• University Hospitals Leuven
  Leuven, Belgium Recruiting
• H.-Hartziekenhuis Roeselare-Menen VZW
  Roeselaere, Belgium Recruiting
• McGill University Health Center
  Montreal, Canada Recruiting
• Copenhagen University Hospital Herlev
  Copenhagen, Denmark Recruiting
• Academic Medical center Maastricht
  Maastricht, Netherlands Recruiting

Study contacts

• Principal investigator: Raf Bisschops, MD PhD — Universitaire Ziekenhuizen KU Leuven
• Study coordinator: Vera Ballet
• Email: vera.ballet@uzleuven.be
• Phone: +3216341601

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.