Comparing two biopsy methods for diagnosing sarcoidosis in lymph nodes
Official title: Evaluating the Diagnostic Yield and Specimen Quality With Endobronchial Ultrasound-Guided Intranodal Forceps Biopsies in Patients With Mediastinal and Hilar Lymphadenopathy: A Prospective Analysis
Run by George Washington University · NCT05374447 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing whether a new biopsy method can find sarcoidosis in lymph nodes better than the standard method for people who might have this condition.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 99 Years |
| Sex | All |
| Enrollment | 55 (estimated) |
| Sponsor | George Washington University Academic / other |
| Locations | 1 site (Washington, District of Columbia) |
| Trial ID | NCT05374447 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older with radiologic evidence of mediastinal and/or hilar lymphadenopathy and a possible diagnosis of sarcoidosis.
✕Probably not a fit
Patients with previously diagnosed sarcoidosis or those who are high risk for general anesthesia may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to compare the diagnostic yield and specimen quality of endobronchial ultrasound-guided intranodal forceps biopsy (EBUS-IFB) with the standard transbronchial needle aspiration (EBUS-TBNA) in patients suspected of having sarcoidosis based on imaging. It is a prospective, single-center randomized study that will enroll 55 patients to assess whether EBUS-IFB provides a higher diagnostic yield than EBUS-TBNA. The study seeks to fill a knowledge gap regarding the effectiveness of these biopsy techniques in diagnosing mediastinal lymphadenopathy. The results could help refine diagnostic approaches for suspected sarcoidosis.
Why it matters
Potential benefit: If successful, this study could improve the accuracy of diagnosing sarcoidosis, leading to better patient management.
How similar studies have gone: Other studies have shown promising results with similar biopsy techniques, indicating potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Radiologic evidence of mediastinal and/or hilar lymphadenopathy * Attending radiologist or pulmonologist reports a possible diagnosis of sarcoidosis * Age 18 years or older Exclusion Criteria\*: These are the characteristics that a participant must NOT have in order to be eligible to participate in the study. Order Number Criteria * Severe pulmonary hypertension * Inability to undergo general anesthesia * Severe coagulopathy or bleeding diathesis * Previously diagnosed sarcoidosis * Patient presently taking clopidogrel * Patient deemed to be high risk for general anesthesia per anesthesiologist * Hemodynamic instability * Mediastinitis * Acute Hypercarbic Respiratory Failure (pCO2 \>55mmHg)
Where it's running
-
The George Washington University Hospital
Washington, District of Columbia, United States Recruiting
Study contacts
- Study coordinator: Khalil Diab, MD
- Email: kdiab@mfa.gwu.edu
- Phone: 2027412180
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Comparing more versus fewer needle agitations during EBUS-TBNA for mediastinal lymph node biopsy
This test will see if using more or fewer needle agitations during EBUS-guided needle biopsies helps doctors obtain longer tissue cores and higher-quality samples in adults with enlarged mediastinal lymph nodes.
-
Cryobiopsy during bronchial endoscopy: safety and how well it works
This project tries cryobiopsy during bronchial endoscopy to see if it is safe and provides better diagnostic tissue for people with mediastinal lesions, enlarged lymph nodes, or diffuse interstitial lung disease.
-
Cryobiopsy for diagnosing mediastinal conditions in Sweden
This study is testing a new biopsy method to see if it helps doctors better diagnose lung and chest conditions like cancer and infections in patients.
-
Improving diagnosis and treatment of mediastinal diseases using ultrasound techniques
This study is testing a new ultrasound technique to see if it helps doctors diagnose and treat mediastinal diseases better than the usual methods.
-
Using hydroxychloroquine to reduce steroid use in patients with extrapulmonary sarcoidosis
This study is testing if hydroxychloroquine can help people with extrapulmonary sarcoidosis manage their symptoms while using fewer steroids.
-
Using semaglutide to treat advanced lung disease
This study is testing if a diabetes and weight loss medication called semaglutide can be safely used by adults with advanced lung diseases to see if it helps them manage their weight better.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.