Comparing three rescue bowel preps for a repeat colonoscopy after poor cleansing
Official title: Comparison of Three Different Rescue Bowel Preparation Regimens in Patients With Previous Bowel Cleansing Failure at Colonoscopy
Run by Ospedale San Pio · NCT07557173 · Data updated 2026-11-12
This test will try three different rescue bowel preparations to see which helps adults get a clean colon before a repeat colonoscopy after a previous preparation failed.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 220 (estimated) |
| Sponsor | Ospedale San Pio Academic / other |
| Locations | 1 site (Benevento) |
| Status | Recruiting |
| Started | January 2, 2024 |
| Main results expected | June 2026 |
| Study ends | June 2026 |
| Registry record updated | May 14, 2026 |
| Trial ID | NCT07557173 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 or older who had an adequately performed but inadequate bowel preparation and are scheduled for a repeat outpatient colonoscopy and can give informed consent.
✕Probably not a fit
Patients with contraindications to any study bowel preparation, known or suspected bowel obstruction or severe gastrointestinal motility disorder, pregnancy or breastfeeding, or who cannot provide informed consent are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized controlled trial enrolls adults who need a repeat outpatient colonoscopy because their prior bowel preparation was inadequate. Participants are randomly assigned to one of three rescue bowel preparation regimens, including a high-volume polyethylene glycol (PEG) plus bisacodyl option and lower-volume PEG with ascorbic acid formulations. The study measures overall and segmental bowel cleansing quality at the repeat colonoscopy and records participant-reported tolerability and satisfaction. Results will compare which regimen achieves the highest rate of adequate cleansing and which is best tolerated.
Why it matters
Potential benefit: If successful, the preferred rescue regimen could increase the number of patients who achieve adequate cleansing on a repeat colonoscopy, reducing repeat procedures and improving detection of lesions.
How similar studies have gone: High-volume PEG and low-volume PEG-plus-ascorbic-acid regimens have been shown effective for primary bowel prep and smaller studies suggest benefit as rescue regimens, but the optimal rescue approach remains uncertain.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged 18 years or older * Prior inadequate bowel preparation (adequately performed) requiring repeat colonoscopy * Scheduled to undergo repeat outpatient colonoscopy * Ability to provide informed consent Exclusion Criteria: * Age younger than 18 years * Inability to provide informed consent * Contraindication to any study bowel preparation regimen or colonoscopy * Known or suspected bowel obstruction or severe gastrointestinal motility disorder * Pregnancy or breastfeeding * Participation considered inappropriate by the investigators for clinical or safety reasons
Where it's running
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San Pio Hospital
Benevento, Italy Recruiting
Study contacts
- Study coordinator: Giuseppe Scaglione
- Email: giuseppe.scaglione@aornsanpio.it
- Phone: +39 360638237
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Cleansing options to improve colonoscopy tolerance
This test compares low-volume tablet bowel preps (Sutab/Suflave) with standard Golytely for adults having outpatient colonoscopies to see which is better tolerated and preferred.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.