Comparing synthetic mammography to full-field digital mammography for breast cancer detection
Official title: Comparison of Synthetic Mammography Versus Full-Field Digital Mammography in Image Interpretation and Performance Metrics
Run by M.D. Anderson Cancer Center · NCT05056818 · Data updated 2026-11-12
This study is testing if synthetic mammography can find breast cancer better and with fewer follow-up appointments than traditional digital mammography.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 750 (estimated) |
| Sponsor | M.D. Anderson Cancer Center Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Houston, Texas) |
| Status | Recruiting |
| Started | December 15, 2020 |
| Main results expected | October 31, 2026 |
| Study ends | October 31, 2026 |
| Registry record updated | October 6, 2026 |
| Trial ID | NCT05056818 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are females aged 18 or older who have undergone breast imaging at the participating center.
✕Probably not a fit
Patients with administrative or technical errors in their imaging records will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study evaluates the effectiveness of synthetic mammography in comparison to full-field digital mammography in interpreting breast images and assessing performance metrics. It leverages data from patients' medical records and past imaging examinations to analyze the characteristics and utility of synthetic mammography, which is a 2D image reconstructed from digital breast tomosynthesis data without additional radiation. The study aims to provide insights into how synthetic mammography may improve breast cancer detection rates and reduce recall rates compared to traditional methods.
Why it matters
Potential benefit: If successful, this study could lead to improved breast cancer detection and reduced unnecessary follow-up procedures for patients.
How similar studies have gone: Previous studies have indicated that digital breast tomosynthesis is superior to standard digital mammography, suggesting that this comparative approach may yield valuable insights.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Female * Age 18 or older * Consecutive cases in breast imaging center Exclusion Criteria: * Cases demonstrate administrative or technical errors (e.g. missing views, labeling inconsistent with report, etc.)
Where it's running
-
M D Anderson Cancer Center
Houston, Texas, United States Recruiting
Study contacts
- Principal investigator: Ray C Mayo — M.D. Anderson Cancer Center
- Study coordinator: Ray C Mayo, MD
- Email: rcmayo@mdanderson.org
- Phone: 713-745-4555
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.