Clinical trial Recruiting at 1 site Observational Ages 18 and up Women only

Comparing synthetic mammography to full-field digital mammography for breast cancer detection

Official title: Comparison of Synthetic Mammography Versus Full-Field Digital Mammography in Image Interpretation and Performance Metrics

Run by M.D. Anderson Cancer Center · NCT05056818 · Data updated 2026-11-12

This study is testing if synthetic mammography can find breast cancer better and with fewer follow-up appointments than traditional digital mammography.

More Breast Carcinoma trials

Quick facts

Study typeObservational
Ages18 Years and up
SexWomen only
Enrollment750 (estimated)
SponsorM.D. Anderson Cancer Center
Academic / other
Drugs / interventionsradiation
Locations1 site (Houston, Texas)
StatusRecruiting
StartedDecember 15, 2020
Main results expectedOctober 31, 2026
Study endsOctober 31, 2026
Registry record updatedOctober 6, 2026
Trial IDNCT05056818 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are females aged 18 or older who have undergone breast imaging at the participating center.

Probably not a fit

Patients with administrative or technical errors in their imaging records will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study evaluates the effectiveness of synthetic mammography in comparison to full-field digital mammography in interpreting breast images and assessing performance metrics. It leverages data from patients' medical records and past imaging examinations to analyze the characteristics and utility of synthetic mammography, which is a 2D image reconstructed from digital breast tomosynthesis data without additional radiation. The study aims to provide insights into how synthetic mammography may improve breast cancer detection rates and reduce recall rates compared to traditional methods.

Why it matters

Potential benefit: If successful, this study could lead to improved breast cancer detection and reduced unnecessary follow-up procedures for patients.

How similar studies have gone: Previous studies have indicated that digital breast tomosynthesis is superior to standard digital mammography, suggesting that this comparative approach may yield valuable insights.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Female
* Age 18 or older
* Consecutive cases in breast imaging center

Exclusion Criteria:

* Cases demonstrate administrative or technical errors (e.g. missing views, labeling inconsistent with report, etc.)

Where it's running

  • M D Anderson Cancer Center
    Houston, Texas, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.