Comparing symptoms in atrophic gastritis and dyspepsia
A Prospective Observational Study on the Correlation Between Pathologically Confirmed Chronic Atrophic Gastritis and Functional Dyspepsia Symptoms
This project will test whether people with pathologically confirmed chronic atrophic gastritis have different types or severity of dyspepsia symptoms than similar patients without atrophic gastritis.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 315 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | The Third Affiliated hospital of Zhejiang Chinese Medical University Academic / other |
| Locations | 1 site (Hangzhou, Zhejiang) |
| Trial ID | NCT07250308 on ClinicalTrials.gov |
What this trial studies
This is a prospective observational comparison of symptom burden in patients who had endoscopic signs suggesting gastric atrophy and underwent standardized gastric biopsies using the Updated Sydney System. Participants will be classified as pathologically confirmed chronic atrophic gastritis (CAG) or non-CAG, and validated symptom questionnaires will measure epigastric pain, burning, early satiety, and postprandial fullness. The study will also collect data on H. pylori status, psychological symptoms, sleep, and dietary factors to explore their contributions to symptom generation. No interventions are given; the goal is to correlate histopathology with symptom profiles to improve diagnostic clarity.
Who should consider this trial
Good fit: Adults aged 18–75 who had a gastroscopy within the past year showing possible atrophic gastritis and who underwent standardized five-point gastric biopsy and can complete questionnaires are ideal candidates.
Not a fit: Patients with gastric cancer, suspected malignant lesions, significant other gastrointestinal diseases, autoimmune gastritis, or those unable to complete the survey are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, the findings could help clinicians better distinguish symptoms linked to precancerous atrophic changes from functional dyspepsia and improve monitoring and management decisions.
How similar studies have performed: Previous studies have shown inconsistent results and are limited by variable pathology criteria, so this project is relatively novel in combining standardized histology (Updated Sydney/OLGA) with validated symptom tools.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age 18-75 years 2. Recent gastroscopic examination (within 1 year) suggesting chronic atrophic gastritis 3. Underwent standardized pathological examination (5-point gastric mucosa biopsy according to the "Updated Sydney System" including antrum, body, and angle) 4. Signed informed consent Exclusion Criteria: 1. Gastric cancer or suspected malignant lesions 2. Concomitant significant other gastrointestinal diseases (e.g., ulcer, Barrett's esophagus, etc.) 3. Autoimmune gastritis 4. Unable to complete questionnaire survey
Where this trial is running
Hangzhou, Zhejiang
- The Third Affiliated Hospital of Zhejiang Chinese Medicinal University — Hangzhou, Zhejiang, China (Recruiting)
Study contacts
- Principal investigator: Yi Liang, PhD — The Third Affiliated Hospital of Zhejiang Chinese Medicial University
- Study coordinator: Yi Liang, PhD
- Email: liangyiwww@126.com
- Phone: +86-571-86633328
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.