Comparing symptoms in atrophic gastritis and dyspepsia
Official title: A Prospective Observational Study on the Correlation Between Pathologically Confirmed Chronic Atrophic Gastritis and Functional Dyspepsia Symptoms
Run by The Third Affiliated hospital of Zhejiang Chinese Medical University · NCT07250308 · Data updated 2026-11-12
This project will test whether people with pathologically confirmed chronic atrophic gastritis have different types or severity of dyspepsia symptoms than similar patients without atrophic gastritis.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 315 (estimated) |
| Sponsor | The Third Affiliated hospital of Zhejiang Chinese Medical University Academic / other |
| Locations | 1 site (Hangzhou, Zhejiang) |
| Status | Recruiting |
| Started | October 1, 2025 |
| Main results expected | July 31, 2026 |
| Study ends | August 31, 2026 |
| Registry record updated | November 26, 2025 |
| Trial ID | NCT07250308 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–75 who had a gastroscopy within the past year showing possible atrophic gastritis and who underwent standardized five-point gastric biopsy and can complete questionnaires are ideal candidates.
✕Probably not a fit
Patients with gastric cancer, suspected malignant lesions, significant other gastrointestinal diseases, autoimmune gastritis, or those unable to complete the survey are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective observational comparison of symptom burden in patients who had endoscopic signs suggesting gastric atrophy and underwent standardized gastric biopsies using the Updated Sydney System. Participants will be classified as pathologically confirmed chronic atrophic gastritis (CAG) or non-CAG, and validated symptom questionnaires will measure epigastric pain, burning, early satiety, and postprandial fullness. The study will also collect data on H. pylori status, psychological symptoms, sleep, and dietary factors to explore their contributions to symptom generation. No interventions are given; the goal is to correlate histopathology with symptom profiles to improve diagnostic clarity.
Why it matters
Potential benefit: If successful, the findings could help clinicians better distinguish symptoms linked to precancerous atrophic changes from functional dyspepsia and improve monitoring and management decisions.
How similar studies have gone: Previous studies have shown inconsistent results and are limited by variable pathology criteria, so this project is relatively novel in combining standardized histology (Updated Sydney/OLGA) with validated symptom tools.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age 18-75 years 2. Recent gastroscopic examination (within 1 year) suggesting chronic atrophic gastritis 3. Underwent standardized pathological examination (5-point gastric mucosa biopsy according to the "Updated Sydney System" including antrum, body, and angle) 4. Signed informed consent Exclusion Criteria: 1. Gastric cancer or suspected malignant lesions 2. Concomitant significant other gastrointestinal diseases (e.g., ulcer, Barrett's esophagus, etc.) 3. Autoimmune gastritis 4. Unable to complete questionnaire survey
Where it's running
-
The Third Affiliated Hospital of Zhejiang Chinese Medicinal University
Hangzhou, Zhejiang, China Recruiting
Study contacts
- Principal investigator: Yi Liang, PhD — The Third Affiliated Hospital of Zhejiang Chinese Medicial University
- Study coordinator: Yi Liang, PhD
- Email: liangyiwww@126.com
- Phone: +86-571-86633328
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.