Comparing standard and accelerated corneal crosslinking for keratoconus treatment
Randomized Comparison of Standard vs. Accelerated Corneal Crosslinking for Treatment of Progressive Keratoconus or Ectasia
This study is testing whether a faster version of corneal crosslinking works better than the standard method for people with keratoconus or corneal ectasia.
Quick facts
| Phase | Phase2; Phase3 |
|---|---|
| Study type | Interventional |
| Enrollment | 510 (estimated) |
| Ages | 10 Years and up |
| Sex | All |
| Sponsor | Price Vision Group Industry-sponsored |
| Locations | 1 site (Indianapolis, Indiana) |
| Trial ID | NCT03922542 on ClinicalTrials.gov |
What this trial studies
This study aims to compare the effectiveness of standard corneal crosslinking versus an accelerated version for patients with progressive keratoconus or corneal ectasia. Participants will receive riboflavin treatment, and their outcomes will be evaluated to determine which method provides better results. The study is designed to assess the safety and efficacy of these two approaches in stabilizing or improving corneal condition. It is conducted in a controlled environment to ensure reliable data collection and analysis.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals diagnosed with progressive keratoconus or corneal ectasia following refractive surgery.
Not a fit: Patients with insufficient corneal thickness or other ocular conditions that may complicate treatment will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a more effective treatment option for patients with keratoconus or corneal ectasia, potentially improving their vision and quality of life.
How similar studies have performed: Other studies have explored corneal crosslinking techniques, but this specific comparison of standard versus accelerated methods is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Documented keratoconus or ectasia after refractive surgery Exclusion Criteria: * Insufficient corneal thickness * Ocular condition that may predispose the eye to complications * History of chemical injury or delayed epithelial healing * Condition that would interfere with or prolong epithelial healing * Known sensitivity to treatment medications * Pregnancy
Where this trial is running
Indianapolis, Indiana
- Price Vision Group — Indianapolis, Indiana, United States (Recruiting)
Study contacts
- Principal investigator: Francis W Price, Jr., MD — Price Vision Group
- Study coordinator: Marianne Price, PhD
- Email: mprice@cornea.org
- Phone: 317-814-2990
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.