Comparing Propofol and Esketamine for Intubation in Critically Ill Patients
Propofol Versus Esketamine for Rapid Sequence Intubation in Critically Ill Patients: A Randomized, Multicenter, Unblinded, Clinical Trial
This study is testing whether Propofol or Esketamine is better for sedating critically ill patients during intubation to see how it affects their recovery right after the procedure.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Enrollment | 170 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Federal University of São Paulo Academic / other |
| Locations | 1 site (São Paulo) |
| Trial ID | NCT05092152 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of two sedative agents, Propofol and Esketamine, during rapid-sequence intubation in critically ill patients experiencing acute respiratory failure. The aim is to determine if these agents affect short-term outcomes, particularly hemodynamic stability, after intubation. Participants will be adults who require intubation as indicated by their physician, and the study will compare the outcomes of those receiving either sedative. The research is being conducted at the Federal University of São Paulo.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years old who require intubation as determined by their physician.
Not a fit: Patients who are pregnant, in cardiac arrest, have known intracranial hypertension, or have allergies to the study medications will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved intubation practices and better patient outcomes in critically ill individuals.
How similar studies have performed: While the specific comparison of Propofol and Esketamine for this purpose may be novel, similar studies on sedative agents in intubation have shown varying degrees of success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age above 18 years old * Physician indicated intubation Exclusion Criteria: * Pregnancy * Intubation during cardiac arrest * Known of suspected intracranial hypertension * Known allergy to propofol or esketamine * Bradycardia (heart rate below 50 beats per minute) or atrioventricular block
Where this trial is running
São Paulo
- Federal University of São Paulo — São Paulo, Brazil (Recruiting)
Study contacts
- Principal investigator: Raysa Schmidt, MD — Federal University of São Paulo
- Study coordinator: Raysa Schmidt, MD
- Email: csraysa@gmail.com
- Phone: +551155764848
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.