Comparing propofol alone versus propofol with clonidine for sedation during colonoscopy
Additive Effects of Clonidine Used in Propofol Sedation in Colonoscopy
This study is testing if adding clonidine to propofol can make sedation during a colonoscopy safer and more comfortable for healthy adults aged 18-65.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 62 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Tanta University Academic / other |
| Locations | 1 site (Tanta, El-Gharbia) |
| Trial ID | NCT06507410 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the safety, satisfaction, and efficiency of propofol sedation compared to a combination of propofol and clonidine in patients undergoing colonoscopy. The research focuses on how the addition of clonidine may enhance sedation effects and reduce the required dosage of propofol, potentially minimizing side effects. By assessing patient outcomes, the study seeks to determine the optimal sedation strategy for improving the overall colonoscopy experience. The trial includes adult participants aged 18-65 who are in good health and undergoing the procedure.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18-65 who are scheduled for a colonoscopy and are in good physical health.
Not a fit: Patients with severe heart failure, recent colonoscopy history, or known hypersensitivity to propofol or clonidine may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved sedation protocols that enhance patient comfort and safety during colonoscopy.
How similar studies have performed: Previous studies have shown promising results with the use of clonidine in sedation protocols, suggesting potential benefits in similar approaches.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18-65 years. * Both sexes. * American Society of Anesthesiology (ASA) physical status I-II. * Patients undergoing colonoscopy. Exclusion Criteria: * Patients had recent history of colonoscopy. * Previous colonic resection. * Severe heart failure (ejection fraction \< 30%). * Known history of hypersensitivity to propofol or clonidine and any need for anesthetic drug administration other than the study protocol.
Where this trial is running
Tanta, El-Gharbia
- Tanta University — Tanta, El-Gharbia, Egypt (Recruiting)
Study contacts
- Study coordinator: Rabab M Mohamed, MD
- Email: rabmoh_30@outlook.com
- Phone: 00201069122935
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.