Comparing prilocaine and bupivacaine effects on elderly patients during spinal anesthesia
Comparison Between the Effect of Prilocaine vs Bupivacaine on Hemodynamics in Spinal Anesthesia for Geriatric Patients Undergoing Endoscopic Urological Surgeries: A Randomized Controlled Trial
This study is testing whether prilocaine or bupivacaine is better for keeping blood pressure and heart rate stable in older patients during certain urological surgeries.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Enrollment | 112 (estimated) |
| Ages | 65 Years and up |
| Sex | All |
| Sponsor | Cairo University Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06165679 on ClinicalTrials.gov |
What this trial studies
This study aims to compare the effects of prilocaine and bupivacaine on hemodynamic stability in geriatric patients undergoing endoscopic urological surgeries. It will involve administering equipotent doses of both local anesthetics to assess their impact on blood pressure and heart rate. The study focuses on patients aged 65 and older, who are classified as ASA I and II. By evaluating these two anesthetics, the research seeks to identify which may provide better hemodynamic outcomes for elderly patients.
Who should consider this trial
Good fit: Ideal candidates for this study are patients aged 65 and older scheduled for endoscopic urological surgeries with ASA I and II classification.
Not a fit: Patients who may not benefit from this study include those with known allergies to local anesthetics, bleeding disorders, or those classified as ASA III and VI.
Why it matters
Potential benefit: If successful, this study could lead to improved anesthetic practices that enhance the safety and comfort of elderly patients during surgery.
How similar studies have performed: While data comparing prilocaine and bupivacaine in elderly patients is limited, similar studies in younger populations have shown varying results, indicating that this approach may provide new insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 65 years old and above. * Both genders. * Patients scheduled to undergo endoscopic urological surgeries. * ASA I and II class. Exclusion Criteria: * Patient refusal. * Known local anesthetic (LA) allergy. * Bleeding disorders. * Skin lesions or infections at site of needle insertion. * Hypertensive patients. * Patients candidate for transurethral resection of the prostate * ASA III and VI class
Where this trial is running
Cairo
- Kasr Alaini hospital — Cairo, Egypt (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.