Comparing post-operative pain from different root canal sealers

The Incidence of Postoperative Pain After Using Different Types of Sealers (A Randomized Clinical Trial)

Not applicable Interventional British University In Egypt · NCT05841290

This study is testing whether using resin-based or silicon-based sealers during root canal treatment causes less pain for patients aged 18-50 with severe tooth issues.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment50 (estimated)
Ages18 Years to 50 Years
SexAll
SponsorBritish University In Egypt Academic / other
Locations1 site (El Shorouk, Cairo Governorate)
Trial IDNCT05841290 on ClinicalTrials.gov

What this trial studies

This clinical trial aims to evaluate and compare the incidence and intensity of post-operative pain experienced by patients after root canal treatment using either resin-based or silicon-based sealers. The study will involve patients aged 18-50 with symptomatic irreversible pulpitis, ensuring they meet specific eligibility criteria regarding their dental and medical conditions. By analyzing the pain levels associated with different sealers, the trial seeks to identify which type may lead to better patient outcomes and reduced discomfort following treatment.

Who should consider this trial

Good fit: Ideal candidates for this study are patients aged 18-50 with symptomatic irreversible pulpitis and normal periapical conditions.

Not a fit: Patients with immature roots, non-restorable teeth, or systemic complications that could affect treatment may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could help identify the most effective root canal sealers to minimize post-operative pain for patients.

How similar studies have performed: Previous studies have explored the impact of different root canal sealers on post-operative pain, suggesting that this approach has potential based on existing literature.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* • Patient's age ranges from 18-50 years old.

  * Patients with teeth diagnosed with symptomatic irreversible pulpitis.
  * Normal periapical condition confirmed by normal periapical radiograph
  * The teeth are restorable
  * Teeth are periodontally free, with no mobility and negative to percussion and palpation test.

Exclusion Criteria:

* • Teeth with immature roots

  * Non restorable teeth
  * Medically compromised patients with systemic complication that would alter the treatment.
  * Necrotic teeth
  * Teeth with apical periodontitis or periapical lesions
  * necrotic Teeth.

Where this trial is running

El Shorouk, Cairo Governorate

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Post Operative PainRoot Canal SealersSillicon Based SealersResin Based Sealers
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.