Comparing Platelet-Rich Plasma Injection and Hydrodissection for Carpal Tunnel Syndrome
Official title: A Prospective Comparative Study on the Efficacy of Ultrasound-Guided Platelet-Rich Plasma Injection Versus Hydrodissection in the Treatment of Carpal Tunnel Syndrome
Run by Mansoura University · NCT06368505 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing whether a new injection treatment or a different technique can help people with Carpal Tunnel Syndrome feel better and improve their hand function.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 64 (estimated) |
| Sponsor | Mansoura University Academic / other |
| Locations | 1 site (Mansoura) |
| Trial ID | NCT06368505 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients diagnosed with Carpal Tunnel Syndrome experiencing symptoms for at least three months.
✕Probably not a fit
Patients who have had previous carpal tunnel surgery or corticosteroid injections may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to evaluate the effectiveness of Ultrasound-Guided Platelet-Rich Plasma (PRP) Injection versus Hydrodissection in treating Carpal Tunnel Syndrome. Participants will be randomly assigned to one of the two treatment groups and will undergo assessments before and after the intervention at 1 and 3 months. The study will measure symptom reduction and functional improvement, as well as the safety profiles of both methods. Ultrasound will be used to guide the injections and assess the condition of the median nerve.
Why it matters
Potential benefit: If successful, this study could provide a more effective treatment option for patients suffering from Carpal Tunnel Syndrome.
How similar studies have gone: Other studies have shown promising results with similar ultrasound-guided interventions, suggesting potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients diagnosed clinically as carpal tunnel syndrome with at least 3 months of symptoms and confirmed electro-physiologically as carpal tunnel syndrome Exclusion Criteria: * Onset of carpal tunnel syndrome during pregnancy * Co-existence of brachial plexopathy or thoracic outlet syndrome by clinical examination * Previous carpal tunnel decompressive surgery or corticosteroid injection in carpal tunnel * Patients with infection or local edema at the site of injection.
Where it's running
-
Mansoura University
Mansoura, Egypt Recruiting
Study contacts
- Study coordinator: osama elshafei, MD, PHD
- Email: osama_elshafei@mans.edu.eg
- Phone: +201211182182
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Matrix Rhythm Therapy for Carpal Tunnel Syndrome
This study tests whether adding Matrix Rhythm Therapy to standard care helps people with mild-to-moderate carpal tunnel syndrome improve symptoms, hand function, grip and pinch strength, and quality of life.
-
Carpal tunnel release vs placebo surgery in Finland
In this trial, people with carpal tunnel syndrome are randomly assigned to either standard carpal tunnel surgery or a pretend surgery to see if relief comes from the operation itself or from placebo effects.
-
High-intensity laser therapy for carpal tunnel syndrome
This trial will test whether high-intensity laser therapy helps adults 18–65 with mild-to-moderate carpal tunnel syndrome reduce pain and improve nerve function and hand strength compared with a sham procedure.
-
Ultrasound-guided needle release plus dextrose (D5W) hydrodissection for carpal tunnel syndrome
This trial tests whether combining ultrasound-guided partial release of the transverse carpal ligament with dextrose (D5W) hydrodissection provides better symptom relief for adults with carpal tunnel syndrome and at least moderate symptoms.
-
A mix of vitamins to help recovery after carpal tunnel surgery
This will test whether taking alpha-lipoic acid, vitamin E, and B vitamins helps adults recover better after carpal tunnel release surgery.
-
Symptom spread and pain sensitivity in carpal tunnel syndrome
This test looks at whether people with carpal tunnel syndrome whose symptoms spread beyond the usual finger area have higher central pain sensitivity, using a questionnaire and pressure pain testing.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.