Comparing platelet-rich plasma and steroid injections for sacroiliac joint pain
Treatment for Sacroiliac Joint Pain Using Platelet-rich Plasma (PRP) Regenerative Therapy: A Randomized Controlled Trial in Comparison With Steroid/Anesthetic Injection With Advanced MR Analysis
This study is testing whether platelet-rich plasma injections work better than steroid injections for people suffering from sacroiliac joint pain.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Utah Academic / other |
| Locations | 2 sites (Salt Lake City, Utah and 1 other locations) |
| Trial ID | NCT05121961 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the effectiveness of platelet-rich plasma (PRP) compared to steroid/anesthetic injections for treating sacroiliac joint pain. Patients diagnosed with sacroiliac joint pain will undergo a physical examination and a diagnostic lidocaine injection to confirm their condition. Eligible participants will be randomly assigned to receive either PRP or steroid/anesthetic injections in a single-blind manner, allowing for an unbiased assessment of treatment outcomes.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old with chronic sacroiliac joint pain confirmed by diagnostic procedures.
Not a fit: Patients with recent steroid treatment, infections, or those on immunosuppressants may not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could provide a more effective and longer-lasting relief for patients suffering from sacroiliac joint pain.
How similar studies have performed: Previous studies have shown promising results for the use of platelet-rich plasma in various musculoskeletal conditions, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult (\>18 y/o) males and females referred for therapeutic injection to the investigators spine interventional service by a physiatrist or pain anesthesiologist with a clinical diagnosis of SIJ pain confirmed by history * 50% or greater reduction in pain by a diagnostic anesthetic block using no more than 1.5 cc 2% lidocaine performed under imaging guidance by a pain interventionalist (PM\&R, Pain Anesthesia, or Neuroradiology Spine Intervention). * Baseline pain must be \>/=4 by numeric rating scale (NRS), at least 6 weeks in chronicity, and must not be multi-factorial (related to radiculopathy or axial pain localizing elsewhere) by physical examination or confounding medical history (infection, inflammatory spondyloarthropathy, or osseous metastatic disease). Exclusion Criteria: * SIJ steroid treatment within the prior 6 months. * Patients with a history of infection currently on antibiotic therapy * Usage of systemic immunosuppressants * Pregnancy
Where this trial is running
Salt Lake City, Utah and 1 other locations
- University of Utah — Salt Lake City, Utah, United States (Recruiting)
- Veterans Administration Salt Lake City Health Care System — Salt Lake City, Utah, United States (Recruiting)
Study contacts
- Principal investigator: Miriam Peckham, MD — University of Utah
- Study coordinator: Ghazaleh Safazadeh
- Email: Ghazaleh.Safazadeh@hsc.utah.edu
- Phone: 801-585-1021
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.