Comparing plant and animal protein effects on older adults' metabolism

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to investigate how plant-based and whey-based proteins influence protein metabolism in older adults, particularly focusing on sarcopenic individuals. Researchers will utilize a sip feeding model to assess the anabolic responses to different protein types, examining the kinetic responses of essential and non-essential amino acids. The study will involve both sarcopenic and non-sarcopenic older adults, stratified by age, and will take place at the Center for Translational Research on Aging and Longevity at Texas A&M University. Participants will undergo screening and several study days, with data collected on body composition and muscle function.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 50-95 years old
* Diagnosis of Chronic Obstructive Pulmonary Disease (COPD); COPD group only
* Stable body-weight (±5%) for the past 3 months
* Ability to walk, sit down, and stand up (independently or with walking assistance device)
* Willingness to lay supine in bed for up to 6 hours
* Willingness and ability to comply with the protocol

Exclusion Criteria:

* Established diagnosis and active treatment of chronic disease: Insulin dependent diabetes mellitus, active malignancy, heart disease, kidney disease, liver disease, HIV/AIDS, Asthma (moderate to severe), Hep (A,B, or C)
* History of untreated metabolic disease including hepatic or renal disorder
* Presence of acute illness or metabolically unstable chronic illness
* Hysterectomy
* Active dependence of alcohol or drugs
* Use of short course of oral corticosteroids within 4 weeks preceding study day
* Current use of long-term oral corticosteroids
* Use of protein or amino acids containing nutritional supplements within 5 days of the first study day
* Presence of fever within the last 3 days
* Planned elective surgery requiring 2 or more days of hospitalization during the entire study
* (Possible) pregnancy
* Failure to give informed consent or Investigator's uncertainty about the willingness or ability of the subject
* Already enrolled in another clinical trial
* Any condition according to the PI or nurse that was found during the screening visit, that would interfere with the study or safety of the patient
* Known allergy to any of the components of the feeding (soy, pea, or whey - dairy)
* Established daily diet of vegetarian / vegan composition
* \<23 MoCa score

Where it's running

• Texas A&M University - CTRAL
  College Station, Texas, United States Recruiting

Study contacts

• Principal investigator: Marielle Engelen, PhD — Texas A&M University
• Study coordinator: Marielle Engelen, PhD
• Email: mpkj.engelen@ctral.org
• Phone: 979-220-2282

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.