Comparing pain relief methods for root canal treatment
Effect of Premedication on Post-endodontic Pain in Patients With Symptomatic Irreversible Pulpitis, a Triple-blinded Randomized Control Trial
This study is testing whether taking alpha-chemo-trypsin, ibuprofen, or acetaminophen before a root canal can help people with tooth pain feel better afterward.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Enrollment | 48 (estimated) |
| Ages | 20 Years to 50 Years |
| Sex | All |
| Sponsor | Gulf Medical University Academic / other |
| Locations | 1 site (Ajman) |
| Trial ID | NCT06671743 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to evaluate the effectiveness of preoperative administration of alpha-chemo-trypsin, ibuprofen, and acetaminophen in reducing post-endodontic pain in patients suffering from symptomatic irreversible pulpitis. Participants will receive one of the three medications before undergoing root canal treatment, and the intensity of pain experienced afterward will be measured and compared. The study seeks to determine which premedication offers the best pain management outcome for these patients.
Who should consider this trial
Good fit: Ideal candidates are patients diagnosed with symptomatic irreversible pulpitis in mandibular molars who are eligible for root canal treatment.
Not a fit: Patients with systemic health issues, allergies to the medications being tested, or those who are pregnant will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved pain management strategies for patients undergoing root canal treatments.
How similar studies have performed: Other studies have explored pain management in dental procedures, but the specific combination of medications in this trial is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Eligibility for root canal treatment Patients diagnosed with symptomatic irreversible pulpitis with normal apical tissue in mandibular molars Exclusion Criteria: * • Patient under any medication or analgesic intake for pain management. * Patients with any systemic health issues * Patient allergies to trypsin-chymotrypsin, ibuprofen, and paracetamol * Pregnancy. * Non-restorable teeth. * Immature roots. * Calcifications. * Resorptions.
Where this trial is running
Ajman
- Gulf Medical University — Ajman, United Arab Emirates (Recruiting)
Study contacts
- Study coordinator: Elsewify
- Email: dr.tarek@gmu.ac.ae
- Phone: +971585078876
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.