Comparing pain relief methods for root canal treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effectiveness of preoperative administration of alpha-chemo-trypsin, ibuprofen, and acetaminophen in reducing post-endodontic pain in patients suffering from symptomatic irreversible pulpitis. Participants will receive one of the three medications before undergoing root canal treatment, and the intensity of pain experienced afterward will be measured and compared. The study seeks to determine which premedication offers the best pain management outcome for these patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Eligibility for root canal treatment Patients diagnosed with symptomatic irreversible pulpitis with normal apical tissue in mandibular molars

Exclusion Criteria:

* • Patient under any medication or analgesic intake for pain management.

  * Patients with any systemic health issues
  * Patient allergies to trypsin-chymotrypsin, ibuprofen, and paracetamol
  * Pregnancy.
  * Non-restorable teeth.
  * Immature roots.
  * Calcifications.
  * Resorptions.

Where it's running

• Gulf Medical University
  Ajman, United Arab Emirates Recruiting

Study contacts

• Study coordinator: Elsewify
• Email: dr.tarek@gmu.ac.ae
• Phone: +971585078876

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.