Comparing pain relief methods for mastectomy patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial compares the effectiveness of liposomal bupivacaine versus bupivacaine with dexmedetomidine in providing postoperative pain relief for patients undergoing mastectomy. It employs a single-blinded randomized control design, where patients are assigned to receive one of the two treatments based on the month of their surgery. The erector spinae plane block will be performed under ultrasound guidance by the Acute Pain Service team, ensuring precise delivery of the anesthetic. The study aims to evaluate the duration of pain relief and the amount of opioids required post-surgery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients requiring any variation of mastectomy with or without axillary lymph node dissection.
* Patient agrees to a peripheral nerve block.
* Patient agrees to be a study participant.
* APS team believes a peripheral nerve block would be appropriate for the patient after reviewing medical/surgical history.
* Surgeon agrees with the block plan by APS.

Exclusion Criteria:

* Patient declines a peripheral nerve block.
* Patient declines to be a study participant.
* APS team believes a peripheral nerve block is not clinically indicated.
* Surgeon does not want a peripheral nerve block.
* Patient has allergy to local anesthestic.
* Patient has an active infection at the site of the peripheral nerve block.
* Patient with pre-existing neural deficits along the distribution of the block.
* Patient with coagulopathy.
* Patient taking antithrombotic drugs outside the ASRA guidelines.
* Patients weight is less that 50 kg due to concerns for local anesthetic toxicity syndrome.

Where it's running

• Naval Medical Center Portsmouth
  Portsmouth, Virginia, United States Recruiting

Study contacts

• Study coordinator: Grant A Miller, DO
• Email: grant.a.miller7.mil@health.mil
• Phone: 757-953-3238

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.