Comparing pain relief from local anesthetic given inside the abdomen versus under the skin after laparoscopic gallbladder removal
Official title: Comparative Evaluation of Analgesic Outcomes of Intra-peritoneal Versus Subcutaneous Infiltration of Bupivacaine for Laparoscopic Cholecystectomy Patients "
Run by Rawalpindi Medical College · NCT07409688 · Data updated 2026-11-12
This trial will try two ways of giving a local anesthetic—inside the abdomen or under the skin—to see which reduces pain after laparoscopic gallbladder removal.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 15 Years to 60 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Rawalpindi Medical College Academic / other |
| Locations | 1 site (Rawalpindi, Punjab Province) |
| Status | Recruiting |
| Started | January 17, 2026 |
| Main results expected | June 17, 2026 |
| Study ends | June 17, 2026 |
| Registry record updated | February 13, 2026 |
| Trial ID | NCT07409688 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults scheduled for elective laparoscopic cholecystectomy who are ASA class I–II, without chronic pain, prior abdominal surgery, or allergy to local anesthetics are ideal candidates.
✕Probably not a fit
Patients with chronic pain, a history of abdominal surgery or open cholecystectomy, or allergy to local anesthetics are excluded and unlikely to benefit from this comparison.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Laparoscopic cholecystectomy removes the gallbladder through small trocar incisions and can still cause postoperative pain at port sites and from intraperitoneal irritation. This phase 4 interventional trial randomizes patients to receive local anesthetic either intraperitoneally or by subcutaneous trocar-site infiltration during surgery. Pain scores and postoperative opioid requirements will be compared between the two groups to determine which route provides better analgesia. The study enrolls ASA I–II adults without chronic pain or prior abdominal surgery at a single center in Rawalpindi.
Why it matters
Potential benefit: If successful, the preferred administration route could reduce postoperative pain and opioid use after laparoscopic gallbladder removal.
How similar studies have gone: Previous studies have shown that local anesthetic techniques can reduce pain after laparoscopy, but head-to-head comparisons of intraperitoneal versus subcutaneous administration remain limited and inconclusive.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * ASA I and II Exclusion Criteria: * Allergic to local anesthetic Open cholecystectomy History of chronic pain History of abdominal surgery
Where it's running
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Rawalpindi Teaching Hospital, Rawalpindi
Rawalpindi, Punjab Province, Pakistan Recruiting
Study contacts
- Study coordinator: Nimrah Iqbal Prinicpal Investigator, MBBS
- Email: drnimrahiqbal@gmail.com
- Phone: +92 335 0526611
Similar studies
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.