Comparing pain relief from gabapentin with and without physiotherapy for carpal tunnel syndrome

Pain Reduction of an Oral Gabapentin and Median Nerve Neural Mobilization Combined Treatment Compared to Only Oral Gabapentin in Subjects Who Suffer Carpal Tunnel Syndrome

Phase 4 Interventional Universidad Europea de Madrid · NCT06778798

This study tests if adding physiotherapy to gabapentin can help people with carpal tunnel syndrome feel less pain and improve their hand function.

Quick facts

PhasePhase 4
Study typeInterventional
Enrollment21 (estimated)
Ages18 Years to 70 Years
SexAll
SponsorUniversidad Europea de Madrid Academic / other
Locations1 site (Valencia, Carabobo)
Trial IDNCT06778798 on ClinicalTrials.gov

What this trial studies

This clinical trial investigates the effectiveness of combining a physiotherapy technique called median nerve neural mobilization with oral gabapentin treatment for patients suffering from carpal tunnel syndrome. Participants will be randomly assigned to receive either the combination treatment or gabapentin alone, allowing for a direct comparison of pain reduction and upper limb functionality. The study aims to determine if the addition of physiotherapy enhances the overall treatment outcomes for this condition.

Who should consider this trial

Good fit: Ideal candidates are individuals diagnosed with unilateral carpal tunnel syndrome who can understand and communicate in Spanish.

Not a fit: Patients with cognitive impairments, recent surgeries, or those currently undergoing other pain treatments may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could provide a more effective pain management strategy for patients with carpal tunnel syndrome.

How similar studies have performed: Previous studies have shown promising results for combining physiotherapy with pharmacological treatments in pain management, suggesting potential success for this approach.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Participants must be medically diagnosed with unilateral carpal tunnel syndrome (with confirmative electrodiagnostic findings).
* Full understanding of written and spoken Spanish (language).
* Participants must freely consent to participate.
* The presence of positive Phalen an Tinel sings.
* The presence of carpal tunnel syndrome signs and symptoms

Exclusion Criteria:

* The lack to meet inclusion criterions, the presence of cognitive impairment, tumors, cancer, recent (affected) upper limb surgery or trauma, pregnancy, kinesiophobia, deformities of the (affected) upper limb, recent skin injuries or infections (in the affected upper limb), autoimmune inflammatory conditions or flu type symptoms, allergy to gabapentin, allergy to ibuprofen arginine, and also: participants must not be (during the present investigation) under any type of pain reducing treatment (conservative, homeopathic, invasive or not invasive)

Where this trial is running

Valencia, Carabobo

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Carpal Tunnel SyndromeGabapentinMedian nerve neural mobilizationPain
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.