Comparing pain relief from exercise in arms and legs
Differences in Exercise-Induced Hypoalgesia at Local and Distal Levels Using Lower and Upper Limb Cycle Ergometer Protocols: A Randomized Controlled Trial in Healthy Participants
PHASE1 · Centro Universitario La Salle · NCT06283186
This study tests if exercising your arms or legs can help reduce pain sensitivity in healthy people.
Quick facts
| Phase | PHASE1 |
|---|---|
| Study type | Interventional |
| Enrollment | 90 (estimated) |
| Ages | 18 Years to 64 Years |
| Sex | All |
| Sponsor | Centro Universitario La Salle (other) |
| Locations | 1 site (Madrid) |
| Trial ID | NCT06283186 on ClinicalTrials.gov |
What this trial studies
This randomized controlled trial investigates how aerobic exercise affects pain sensitivity in healthy individuals by comparing three groups: one exercising on a lower limb cycle ergometer, another on an upper limb cycle ergometer, and a control group. Participants will engage in 30 minutes of aerobic activity at 70-80% of their heart rate reserve. The study will measure changes in pressure pain thresholds in both the thigh and elbow to assess exercise-induced hypoalgesia. The goal is to determine if the location of exercise influences pain relief in different body regions.
Who should consider this trial
Good fit: Ideal candidates are healthy individuals aged 18 to 64 without any significant medical history.
Not a fit: Patients with cardiovascular, respiratory, metabolic, neurological, or osteomuscular conditions, as well as those experiencing pain, will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into effective pain management strategies through exercise.
How similar studies have performed: While the concept of exercise-induced hypoalgesia has been explored, this specific comparative approach is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Asymptomatic subjects aged between 18 and 64 years. Exclusion Criteria: * Cardiovascular, respiratory, metabolic, neurological, or osteomuscular signs or pathologies. * History of epilepsy. * Pregnant * Pharmacological treatment. * Participants who present any type of pain on the day of the measurements or who have frequently suffered pain during the previous 12 weeks.
Where this trial is running
Madrid
- CSEU LaSalle — Madrid, Spain (RECRUITING)
Study contacts
- Study coordinator: Álvaro Reina-Varona, MSc
- Email: alvaro.reina@lasallecampus.es
- Phone: 0034+649001863
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Healthy Subjects, Local Hypoalgesia, Distal Hypoalgesia, Aerobic Exercise, Pressure Pain Thresholds