Comparing pain modulation in localized and widespread chronic low back pain
Determining if Conditioned Pain Modulation Differs Between Individuals With Localized Versus Widespread Mechanical Pain Hypersensitivity in Chronic Low Back Pain
Ahram Canadian University · NCT05972395
This study looks at how well the body can manage pain in people with chronic low back pain by comparing those with pain in one area to those with pain all over.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 75 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | Ahram Canadian University (other) |
| Locations | 1 site (Al Ḩayy Ath Thāmin, Giza) |
| Trial ID | NCT05972395 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the body's natural pain modulation system in individuals suffering from chronic low back pain (CLBP) by comparing those with localized pain to those with widespread pain. Researchers will measure pain inhibition through pressure pain thresholds before and during cold water hand immersion. The hypothesis is that individuals with widespread pain will exhibit poorer pain modulation compared to those with localized pain. The findings may lead to more personalized approaches in managing chronic pain based on the type of pain experienced.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-60 with chronic low back pain lasting more than three months and an average pain intensity of at least 4 out of 10.
Not a fit: Patients with known low back pathologies, previous lumbar surgery, neuropathic low back pain, or comorbid generalized pain conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance personalized pain management strategies for patients with chronic low back pain.
How similar studies have performed: While studies have documented impairments in pain modulation in chronic low back pain populations, this specific comparison between localized and widespread pain is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Ages 18-60 years * Chronic LBP \>3 months * Average LBP intensity ≥4/10 Exclusion Criteria: * Known LBP pathologies * Previous lumbar surgery * Neuropathic LBP * Comorbid generalized pain conditions
Where this trial is running
Al Ḩayy Ath Thāmin, Giza
- Outpatient clinic of faculty of physical therapy, Ahram Canadian University — Al Ḩayy Ath Thāmin, Giza, Egypt (RECRUITING)
Study contacts
- Study coordinator: Mohamed M ElMeligie, Ph.d
- Email: mohamed.elmeligie@acu.edu.eg
- Phone: +201064442032
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Chronic Low-back Pain