Comparing noradrenaline and phenylephrine effects on blood flow during brain surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to determine the optimal vasopressor for maintaining organ blood flow and tissue oxygen delivery during neurosurgery in patients with brain tumors. It involves a randomized, double-blinded design where participants will receive either noradrenaline or phenylephrine infusion. The study will utilize PET scans to measure blood flow and oxygen consumption in the brain and other vital organs before surgery. A total of 32 patients aged 18 to 75 with diagnosed brain tumors will be enrolled for this investigation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Clinical diagnosis of supratentorial malignant or non-malignant brain tumors. Preferably 3 cm or larger( measured as the largest diameter in any plane on MRI).
2. Scheduled for elective supratentorial craniotomy.
3. Patients aged between 18 and 75 years.
4. American Society of Anesthesiologists status 1-3

Exclusion Criteria:

1. History of allergy or intolerance to one of the study medications.
2. Active treatment with monoamine oxidase inhibitors.
3. An American Society of Anesthesiologists (ASA)physical status IV-VI.
4. Pregnancy or breastfeeding.
5. Inability to provide written informed consent -

Where it's running

• Aarhus University Hospital
  Aarhus, Denmark Recruiting

Study contacts

• Principal investigator: Mads Rasmussen, MD, PhD — Aarhus University Hospital
• Study coordinator: Rasmussen
• Email: mads.rasmussen@vest.rm.dk
• Phone: 004529265713

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.