Comparing new nasal interface with standard cannula for COPD patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to compare the effectiveness of a new asymmetric nasal high flow interface against a conventional high flow nasal cannula in patients experiencing acute exacerbation of COPD. Participants will wear each type of cannula for three hours, with a 30-minute break in between, while various clinical parameters and arterial blood samples are collected. The study will assess differences in carbon dioxide levels, respiratory rate, dyspnea, and the need for advanced oxygen therapy. The research is conducted at two hospitals in Greece, following a randomized crossover design.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* acute exacerbation of COPD (defined as any worsening of the patient's respiratory symptoms that is beyond normal day-to-day variations and leads to change in medication)
* mild-to-moderate acute hypercapnic respiratory failure (defined as 7.35\>pH\>7.25 and arterial CO2 tension (PaCO2) \>45 mmHg)

Exclusion Criteria:

* acute on chronic hypercapnic respiratory failure
* severe facial deformity, facial burns, fixed upper airway obstruction
* indication for imminent intubation and invasive mechanical ventilation (i.e. respiratory or cardiac arrest, diminished consciousness (Glasgow coma score \<8)
* psychomotor agitation inadequately controlled by sedation
* massive aspiration
* persistent inability to remove respiratory secretions
* severe haemodynamic instability unresponsive to fluids and vasoactive drugs
* severe ventricular or supraventricular arrhythmias
* life threatening hypoxaemia

Where it's running

• Sotiria General Hospital
  Athens, Greece Recruiting
• University Hospital of Larissa
  Larissa, Greece Recruiting

Study contacts

• Study coordinator: Ioannis Pantazopoulos, Ph.D.
• Email: pantazopoulosioannis@yahoo.com
• Phone: 6945661525

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.