Comparing neoadjuvant chemoradiotherapy and chemotherapy for advanced breast cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of preoperative treatment options for luminal-type locally advanced breast cancer by comparing neoadjuvant chemotherapy with neoadjuvant stereotactic body radiotherapy (SBRT) combined with chemotherapy. Utilizing advanced radiotherapy technologies, the study aims to assess outcomes such as the pathological complete response rate, the rate of breast-conserving surgery, progression-free survival, and treatment-related side effects. The goal is to identify new strategic options that could improve treatment outcomes for patients with this type of breast cancer.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Pathologically confirmed invasive breast cancer ;
2. Breast MRI showing stages IIB to IIIC (2017 AJCC 8th edition staging);
3. Clinical staging confirmed by chest MRI and/or axillary ultrasound, as well as CT scans of the neck, abdomen, and pelvis, and bone scintigraphy, including T and N staging and assessment of distant metastasis;
4. Karnofsky performance score ≥80 or ECOG performance status of 0-1;
5. No history of allergies to doxorubicin, cyclophosphamide, paclitaxel/docetaxel;
6. No prior exposure to radiotherapy, chemotherapy, endocrine therapy, targeted therapy, or immunotherapy.

Exclusion Criteria:

1. History of malignancy at other sites, excluding curable non-melanoma skin cancer and carcinoma in situ of the cervix;
2. Inability to complete MRI;
3. Inflammatory breast cancer;
4. Bilateral or multifocal primary tumors;
5. Active infection currently present; clinically evident heart disease; myocardial infarction or cerebrovascular accident within 6 months prior to enrollment.

Where it's running

• Sichuan Cancer Hospital
  Chengdu, Sichuan, China Recruiting

Study contacts

• Principal investigator: Qian Peng, Phd — Sichuan Cancer Hospital and Research Institute
• Study coordinator: Qian Peng, Phd
• Email: pengqian@scszlyy.org.cn
• Phone: 86-028-85420059

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.