Comparing muscle activity in amputees and non-amputees
Comparing Intact and Residual Amputated Neuromuscular Physiology
NA · North Carolina State University · NCT06182202
This study tests how muscle activity differs between lower limb amputees and non-amputees during everyday tasks to help improve prosthetic designs.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 18 Years to 64 Years |
| Sex | All |
| Sponsor | North Carolina State University (other) |
| Locations | 1 site (Raleigh, North Carolina) |
| Trial ID | NCT06182202 on ClinicalTrials.gov |
What this trial studies
This study investigates the differences in neuromuscular physiology between lower limb amputees and non-amputees by analyzing muscle activity during various functional tasks. Approximately 80 participants will be involved, with half being unilateral lower-limb amputees and the other half being non-amputees. Participants will perform controlled muscle activities and functional tasks while their muscle activation, architecture, and biomechanics are recorded using advanced techniques like electromyography and ultrasound. The findings aim to enhance the design of prosthetic devices by better understanding how amputees control their muscles.
Who should consider this trial
Good fit: Ideal candidates include unilateral lower-limb amputees and healthy individuals aged 18 and older who can walk unassisted.
Not a fit: Patients with cognitive, visual, or balance impairments, or those with certain medical conditions like heart disease or stroke, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved prosthetic control and functionality for amputees, enhancing their independence and quality of life.
How similar studies have performed: While there is ongoing research in prosthetic control and muscle activity, this specific comparative approach between amputated and non-amputated muscle is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria for Individuals without Amputation: * Live in the United States * Are 18 years of age or older * Can walk across low-level environmental barriers such as curbs, stairs, or uneven surfaces unassisted and without much difficulty Exclusion Criteria for Individuals without Amputation: - Have any cognitive, visual, or balance impairments that affects your ability to provide informed consent or to follow instructions during the experiments * Have had a stroke * Have heart disease * Weigh 450 pounds or more (for harness safety) * Have a girth/waist circumference more than 49 inches (124.4 cm) (for harness safety) * Have allergies to adhesives Inclusion Criteria for Individuals with Amputation: * Live in the United States * Are a unilateral lower-limb amputee * Have lower limb length from the knee to where the amputation occurred at least 10cm long * Can walk across low-level environmental barriers such as curbs, stairs, or uneven surfaces unassisted and without much difficulty Exclusion Criteria for Individuals with Amputation: - Have any cognitive, visual, or balance impairments that affects your ability to provide consent or to follow instructions during the experiments * Have had a stroke * Have heart disease * Had skin lesions/incomplete healing following amputation * Have ulcers * Have lower limb length from the knee to where the amputation occurred less than 10cm long * Weigh 450 pounds or more (for harness safety) * Have a girth/waist circumference more than 49 inches (124.4 cm) (for harness safety) * Have allergies to adhesives
Where this trial is running
Raleigh, North Carolina
- North Carolina State University — Raleigh, North Carolina, United States (RECRUITING)
Study contacts
- Study coordinator: Ming Liu, PhD
- Email: mliu10@ncsu.edu
- Phone: 919-515-8541
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Amputation, Amputees, Electromyography, Ultrasound, Neuromuscular Physiology, Prostheses, Muscle Activation