Comparing methods to clean dental implants affected by peri-implantitis
Efficacy of Non-surgical and Surgical Surface Decontamination Methods on Peri-implantitis-affected Implants: A Randomized Clinical Trial
This study is testing two different ways to clean dental implants that have infection to see which method works better for patients.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 90 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | University of Pittsburgh Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Pittsburgh, Pennsylvania) |
| Trial ID | NCT06430268 on ClinicalTrials.gov |
What this trial studies
This study compares two methods for cleaning contaminated dental implant surfaces: an air-polishing device and a titanium curette. Both methods will be evaluated in non-surgical and surgical settings, followed by the removal of the implants. Participants will undergo screening to determine eligibility, and various parameters related to the implants and surrounding tissues will be assessed. The study aims to analyze the effectiveness of these decontamination methods through in-vitro analysis after implant removal.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 80 who require the removal of at least one titanium implant due to severe peri-implantitis.
Not a fit: Patients with acute infections, certain medical conditions, or those who have undergone recent peri-implant therapy may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve treatment outcomes for patients with peri-implantitis by identifying more effective decontamination methods.
How similar studies have performed: Other studies have explored various decontamination methods for dental implants, indicating potential for success in this area.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria: * Adult individuals between 18 and 80 years of age who require the explantation of at least one titanium or titanium alloy implant due to severe peri-implantitis (\> 50% bone loss and signs of inflammation); * Individuals who did not undergo surgical or non-surgical peri-implant therapy in the previous 6 months. Exclusion criteria: * Acute infection associated with adjacent teeth; * Any technical complication that does not allow implant removal using a reverse torque device; * Active infectious diseases of any kind; * Medical conditions which requires premedication prior to dental treatments/visits; * Pregnant women or planning to become pregnant (self-reported); * History of radiotherapy in the head and neck or chemotherapy in the last 3 years; * Any other diseases or medications that may contraindicate the surgical procedure or compromise wound healing.
Where this trial is running
Pittsburgh, Pennsylvania
- University of Pittsburgh, School of Dental Medicine — Pittsburgh, Pennsylvania, United States (Recruiting)
Study contacts
- Principal investigator: Andrea Ravida, DDS MS PhD — University of Pittsburgh
- Study coordinator: Andrea Ravida, DDS MS PhD
- Email: ANDREARAVIDA@PITT.EDU
- Phone: (734) 730-9678
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.