Comparing metformin and doxycycline for treating moderate to severe acne
Comparative Study of Metformin Versus Doxycycline in Treatment of Moderate to Severe Adult Acne Vulgaris Patients: Multicentre, Randomized, Double-blind Trial.
This study is testing whether metformin or doxycycline works better to treat moderate to severe acne in patients.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Enrollment | 120 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh Academic / other |
| Locations | 1 site (Dhaka) |
| Trial ID | NCT06252194 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to compare the effectiveness of metformin versus doxycycline in treating patients with moderate to severe acne vulgaris. Participants will be divided into two groups, with one group receiving doxycycline along with topical treatments and the other group receiving metformin with topical treatments. The researchers will evaluate and compare the clinical improvement in acne symptoms between the two groups to determine which treatment is more effective.
Who should consider this trial
Good fit: Ideal candidates for this study are adults who have been newly diagnosed with moderate to severe acne vulgaris by a dermatologist.
Not a fit: Patients who have used topical retinoids in the last two months, are pregnant or lactating, have a history of corticosteroid use, or suffer from malignancy or cosmetic-induced acne may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a more effective treatment option for patients suffering from moderate to severe acne vulgaris.
How similar studies have performed: While there have been studies on the use of doxycycline for acne, the comparison with metformin is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Newly diagnosed moderate and severe AV patients diagnosed by a dermatologist - Exclusion Criteria: * Patients receiving topical retinoids within last two months * Pregnancy and lactation * History of corticosteroids intake * Suffering from malignancy or any cosmetic induced acne
Where this trial is running
Dhaka
- Bsmmu — Dhaka, Bangladesh (Recruiting)
Study contacts
- Study coordinator: Muhammad Marnush, MBBS
- Email: marnushm@gmail.com
- Phone: 88001714558447
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.