Comparing medical treatment effects in patients with intracranial atherosclerosis
Official title: Effects of Medical Treatment of Intracranial Atherosclerotic Diseases Based on Magnetic Resonance Fractional Flow Reserve
Run by Xuanwu Hospital, Beijing · NCT06196398 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing how well standard medical treatment works for people with symptomatic intracranial atherosclerosis to see if it can help prevent strokes or death over a year.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 30 Years to 80 Years |
| Sex | All |
| Enrollment | 400 (estimated) |
| Sponsor | Xuanwu Hospital, Beijing Academic / other |
| Locations | 1 site (Beijing, Beijing) |
| Trial ID | NCT06196398 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients aged 30 to 80 with symptomatic ICAS lesions in the anterior circulation and 50% to 99% stenosis confirmed by imaging.
✕Probably not a fit
Patients with previous cerebrovascular interventions, large cerebral infarctions, or other significant neurological conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This multicenter prospective cohort study evaluates the impact of medical treatment on patients with symptomatic intracranial atherosclerosis (ICAS) over one year. Patients are divided into groups based on hemodynamic status assessed by Magnetic Resonance Fractional Flow Reserve (MR-FFR). The primary outcome measures include the occurrence of ischemic stroke or death related to the artery territory within the study period. Standard medical treatment, including anti-platelet therapy, will be administered to all participants.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment strategies for patients with intracranial atherosclerosis, potentially reducing the risk of stroke and death.
How similar studies have gone: While this approach is innovative, similar studies have shown promise in assessing hemodynamic factors in stroke prevention, suggesting potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients aged from 30 to 80 with symptomatic ICAS lesion in anterior circulation. 2. 50% to 99% stenosis (in accordance with modified WASID method) confirmed by DSA, CTA or MRA. 3. mRS 0-2 points 4. Informed of the study protocol and objectives. Exclusion Criteria: 1. Previous endovascular treatment or surgery for cerebrovascular diseases 2. Large cerebral infarction (more than 1/2 MCA perfusion area) according to MRI 3. Combined with other neurological diseases, such as aneurysm, arteriovenous malformation, tumor, hydrocephalus, cerebral trauma, cerebral hemorrhage, multiple sclerosis, epilepsy and intracranial infection. 4. Pregnancy or in the preparation for pregnancy 5. Patients who cannot tolerate or do not allow MR screening, including metal implanting and claustrophobia 6. Contraindication for antiplatelet drugs or statins 7. Patients with severe dementia or mental disorders, who cannot cooperate with examination
Where it's running
-
Xuanwu Hospital, Capital Medical University
Beijing, Beijing, China Recruiting
Study contacts
- Study coordinator: Jichang Luo
- Email: luojichang_dr@sina.com
- Phone: +8613120136577
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.