Comparing low tidal volume and airway pressure release ventilation for ARDS patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effects of low tidal volume ventilation (LTV) and airway pressure release ventilation (APRV) on lung tissue mechanics in adults diagnosed with Acute Respiratory Distress Syndrome (ARDS). The study will involve a prospective randomized crossover design, where participants will receive both ventilation methods to determine which one better improves lung mechanics and enhances patient safety. The trial will include patients who are within 12 hours of starting invasive mechanical ventilation and will assess their response to each ventilation mode.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Meets the diagnostic criteria of the 2023 Global New Definition of ARDS.
2. Age: 18-80 years.
3. PaO2/FiO2 ≤ 200.
4. Within 12 hours of invasive mechanical ventilation treatment.
5. Obtain consent from the patient or their family members to participate in the study, and sign the informed consent form.

Exclusion Criteria:

1. Age \< 18 years or \> 80 years.
2. Uncorrected shock of any type.
3. Chronic obstructive pulmonary disease (COPD), pulmonary embolism, right heart failure, pulmonary hypertension, or severe arrhythmia.
4. Contraindications for using Electrical Impedance Tomography (EIT) (extensive chest skin damage, infection, pacemaker implantation, implanted automatic defibrillator, etc.), pneumothorax, mediastinal emphysema, or large pleural effusion.
5. Pregnant or breastfeeding women.
6. Patients planned for ECMO treatment.
7. Patients currently participating in or previously enrolled in other clinical studies.

Where it's running

• Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
  Wuhan, Hubei, China Recruiting

Study contacts

• Study coordinator: Xiaojing Zou Professor
• Email: 13995518630@163.com
• Phone: 13995518630

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Pulse Wave vs Saline Bolus EIT to measure lung perfusion in ARDS

  This study tests whether pulse wave EIT or saline bolus EIT can best show lung blood flow in ARDS patients on mechanical ventilation.

  Recruiting Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei · NCT07908368

• Biorepository and endotyping study for ARDS patients

  This observational study tests whether creating a centralized ARDS biorepository and data set can help develop endotype and treatment-prediction tools for adults with ARDS.

  Recruiting Prenosis, Inc. · Urbana, Illinois · NCT07675265

• BAL balance: ARDS through lung lavage and imaging to find different ARDS types

  This study tests how bronchoalveolar lavage fluid and chest CT imaging can reveal different ARDS subtypes in adults with ARDS or severe pneumonia in the ICU.

  Recruiting Medical University of Vienna · Vienna, State of Vienna · NCT07633366

• Titrating PEEP in ARDS: Manual chest compression vs. electrical impedance tomography

  In adults with ARDS on mechanical ventilation, the study tests whether a simple manual chest compression method can set the right PEEP as well as electrical impedance tomography (EIT).

  Recruiting at 2 sites Centre Hospitalier Saint Joseph Saint Luc de Lyon · Créteil and 1 other locations · NCT07623590

• Individualized PEEP Titration in ARDS Based on Lung Recruitment Potential

  This pilot study tests two personalized PEEP strategies in adults with ARDS to see which approach better supports breathing mechanics by using a recruitment potential measure.

  Recruiting Hospital Dr. Franco Ravera Zunino · Rancagua, Región del Libertador General Bernardo O’Higgins · NCT07603310

• Single-dose inhaled rh-KGF-2 for ARDS in adults

  This trial tests whether a single inhaled dose of rh-KGF-2 helps adults with ARDS who are on ventilators, using three dose levels to see which is safest and potentially most effective.

  Recruiting Early Phase 1 Shanghai Zhongshan Hospital · Shanghai, Shanghai Municipality · NCT07558538

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.