Comparing Low Glycemic Index Diet and Classic Ketogenic Diet for Treating Pediatric Epilepsy
Comparison of the Effect of Low Glycemic Index Diet Compared to the Classical Ketogenic Diet in Reducing the Number of Seizures in Children With Drug Resistant Epilepsy
This study is trying to see if a Low Glycemic Index diet or a Classic Ketogenic diet works better to reduce seizures in children with epilepsy who haven't found relief from medications.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 2 Years to 18 Years |
| Sex | All |
| Sponsor | Mashhad University of Medical Sciences Academic / other |
| Locations | 1 site (Mashhad, Razavi Khorasan) |
| Trial ID | NCT06703983 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of two dietary interventions, the Low Glycemic Index Therapy (LGIT) and the Classic Ketogenic Diet (CKD), in treating children with drug-resistant epilepsy. It aims to determine which diet is more effective in reducing seizures among children aged 2 to 18 who have not responded to at least two antiepileptic medications. The study will involve a controlled intervention where participants will follow either diet under supervision to assess adherence and seizure frequency. The findings could provide insights into dietary management options for pediatric epilepsy.
Who should consider this trial
Good fit: Ideal candidates for this study are children aged 2 to 18 years who continue to experience seizures despite being treated with two or more antiepileptic medications.
Not a fit: Patients with liver or kidney diseases, or those whose parents do not approve of participation, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could offer a more manageable dietary treatment option for children with drug-resistant epilepsy, potentially improving their quality of life.
How similar studies have performed: Previous studies have shown varying success with dietary therapies for epilepsy, but this specific comparison of LGIT and CKD is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Children between 2 and 18 years old who still have epilepsy despite receiving 2 or more medications Children with genetic disease need to receive ketogenic diet (pyruvate dehydrogenase deficiency and GLUT-1 transporter deficiency) Exclusion Criteria: Parents' disapproval of the child's participation in the study Having liver and kidney diseases Doctor's disapproval based on the patient's condition Absolute contraindications to the ketogenic diet
Where this trial is running
Mashhad, Razavi Khorasan
- Mashhad University of Medical Sciences — Mashhad, Razavi Khorasan, Iran, Islamic Republic of (Recruiting)
Study contacts
- Study coordinator: Saman Sepehrar, MSc Student of Nutrition
- Email: samansepehrar1024@gmail.com
- Phone: 009809375524481
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.