Comparing low dose vasopressin and phenylephrine in heart surgery
Low Dose Vasopressin vs Phenylephrine in Cardiac Surgery
This study tests whether a low dose of vasopressin works better than phenylephrine to help prevent kidney problems during heart surgery for adults.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 300 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Thomas Jefferson University Academic / other |
| Locations | 1 site (Philadelphia, Pennsylvania) |
| Trial ID | NCT04602767 on ClinicalTrials.gov |
What this trial studies
This study investigates the effectiveness of vasopressin versus phenylephrine as the first-line vasopressor during cardiac surgery. It is a randomized, open-label trial involving patients over 18 years old who are undergoing coronary artery bypass grafting or valve surgery. The primary focus is on preventing acute kidney injury, with secondary outcomes including mortality and other complications. Patients will be monitored for mean arterial blood pressure maintenance during the perioperative period.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old scheduled for coronary artery bypass grafting or valve surgery.
Not a fit: Patients with severe heart conditions, such as low ejection fraction or significant pulmonary hypertension, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved kidney function and reduced complications in patients undergoing cardiac surgery.
How similar studies have performed: Other studies have explored vasopressors in cardiac surgery, but this specific comparison is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * \>18 years of age * Coronary artery bypass graft (CABG), valve, or combined CABG and valve surgery Exclusion Criteria: * Ejection fraction \< 35% * \> moderate pulmonary hypertension * \> mild right ventricular dysfunction * Radial arterial graft * Circulatory arrest
Where this trial is running
Philadelphia, Pennsylvania
- Thomas Jefferson Univesity — Philadelphia, Pennsylvania, United States (Recruiting)
Study contacts
- Study coordinator: Jenifer Lessin
- Email: jennifer.lessin@jefferson.edu
- Phone: 215 955-5804
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.