Comparing low dose morphine with dexmedetomidine to standard morphine for pain management in children

Comparison of Addition of Dexmedetomidine to Low Dose Morphine Versus Standard Dose of Morphine in Patiant Controlled Analgesia in Children Undergoing Pelvi Abdominal Exploration. a Prospective Randomized Trial

This study is testing if using a lower dose of morphine with another medication can help kids aged 8 to 12 manage pain better after surgery compared to regular morphine.

Quick facts

• Phase: NA
• Study type: Interventional
• Enrollment: 60 (estimated)
• Ages: 8 Years to 12 Years
• Sex: All
• Sponsor: Beni-Suef University (other)
• Locations: 1 site (Egypt)
• Trial ID: NCT05688371 on ClinicalTrials.gov

What this trial studies

This study evaluates the effectiveness of combining low dose morphine with dexmedetomidine versus using a standard dose of morphine in patient-controlled analgesia (PCA) for children aged 8 to 12 years undergoing exploratory surgery. The goal is to improve postoperative pain management by allowing children to self-administer analgesics while minimizing opioid use. The study will assess pain relief and any potential side effects associated with the different treatment regimens.

Who should consider this trial

Good fit: Ideal candidates are children aged 8 to 12 years who are ASA I or II and scheduled for exploratory surgery under general anesthesia.

Not a fit: Patients with a history of allergy to morphine or dexmedetomidine, mental disorders, or significant comorbidities may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could lead to improved pain management in children with reduced reliance on higher doses of opioids.

How similar studies have performed: While there is ongoing interest in optimizing pain management in pediatric populations, this specific combination of low dose morphine and dexmedetomidine in PCA is relatively novel.

Eligibility criteria

Inclusion Criteria:

1. ASA I \& II of both sex.
2. Age between 8 and 12 years.
3. Patients scheduled for exploration surgery under general anesthesia.

Exclusion Criteria:

1. Parents refused to give consent.
2. Patients with history of allergy to morphine or dexmedetomidine.
3. Mental disorders.
4. Unsuitability for extubation.
5. Comorbidities as cardiac, pulmonary and obstructive sleep apnea.
6. children with chronic opioid use for \> 3 monthes

Where this trial is running

Egypt

• Benisuef University Hospital — Egypt, Egypt (RECRUITING)

Study contacts

• Principal investigator: Mariana abdelsayed Mansour, Lecturer — Benisuef university hospital
• Study coordinator: Mariana abdelsayed Mansour, MD

Conditions: PCA, Children, Dexmedetomidine, Morphine