Comparing live birth rates in natural cycle embryo transfers with and without hormone support
Official title: Comparison of Live Birth Rate (> 24 Weeks) in Natural Cycle (NC) Single Euploid Frozen Embryo Transfers (FET) With Versus Without Luteal Phase Support (LPS)
Run by ART Fertility Clinics LLC · NCT05969795 · Data updated 2026-11-12
This study is testing if women can have the same chance of a live birth with a natural embryo transfer without hormone support as they do with hormone support.
Quick facts
| Phase | Phase 1 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 40 Years |
| Sex | Women only |
| Enrollment | 342 (estimated) |
| Sponsor | ART Fertility Clinics LLC Academic / other |
| Locations | 3 sites (Abu Dhabi and 2 other locations) |
| Status | Recruiting |
| Started | September 5, 2023 |
| Main results expected | April 30, 2026 |
| Study ends | September 30, 2026 |
| Registry record updated | January 9, 2025 |
| Trial ID | NCT05969795 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women aged 18 to 40 with regular ovulatory cycles and at least one euploid embryo available for transfer.
✕Probably not a fit
Patients with anatomical changes affecting implantation or a history of repeated pre-menstrual spotting may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of single euploid embryo transfer in natural cycles (NC) without routine luteal phase support (LPS) compared to those with LPS. The goal is to determine if the live birth rate in NC cycles without LPS is non-inferior to those with LPS. If successful, this could simplify treatment protocols and enhance patient comfort. Participants will undergo transvaginal ultrasounds and serum hormone level monitoring as part of the intervention.
Why it matters
Potential benefit: If successful, this study could lead to simpler and more comfortable fertility treatments for women undergoing embryo transfer.
How similar studies have gone: Other studies have explored similar approaches, but this specific comparison of LPS in natural cycles is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age: 18 to 40 years * Regular ovulatory cycles * Availability of at least one euploid embryo after Trophectoderm biopsy for PGT-A on day 5 or day 6 * Detection of ovulation by P4 rise \> 1.0 ng/ml after LH surge * P4 value of at least 5 ng/ml on day 4 after ovulation Exclusion Criteria: * History of repeated pre-menstrual spotting * Factors affecting the implantation through anatomical changes of the uterus / ovaries or the tubes (adenomyosis, Asherman syndrome, endometriosis, uterine fibroids / polyps, isthmocele with intracavitary fluid presence, hydrosalpinx….)
Where it's running
-
ART Fertility Clinics LLC
Abu Dhabi, United Arab Emirates Recruiting -
ART Fertility Clinics Al Ain
Al Ain City, United Arab Emirates Recruiting -
ART Fertility Clinics Dubai
Dubai, United Arab Emirates Not yet recruiting
Study contacts
- Principal investigator: Barbara Lawrenz, PhD — ART Fertility Clinics LLC
- Study coordinator: Barbara Lawrenz, PhD
- Email: barbara.lawrenz@artfertilityclinics.com
- Phone: +971 800 337845489
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.