Comparing lithium and lamotrigine for treating Bipolar II Disorder

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to compare the effects of lithium carbonate and lamotrigine on mood stabilization and other important outcomes in patients diagnosed with Bipolar II Disorder. Conducted over a 6-month period, the study will utilize a randomized controlled trial design to assess the efficacy of these two commonly used medications. The research addresses a significant gap in understanding the pharmacological treatment options for Bipolar II Disorder, which is often overlooked despite its prevalence and impact on patients' lives.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Bipolar disorder, type II with diagnosis confirmed by SCAN interview
* Age 18-70 years
* Habile (i.e., able to give informed consent)

Exclusion Criteria:

* Past non-response or intolerance to lamotrigine or lithium with \> 6 weeks treatment at an adequate dosage
* Currently taking mood stabilizers at enrollment in CADIC
* Severe chronic kidney disease
* Severe cardiac insufficiency
* Brugadas syndrome
* Severe hypothyroidism despite treatment
* Women who are pregnant, breastfeeding or planning pregnancy in near future.

Where it's running

• Psychiatric Center Copenhagen
  Copenhagen, Denmark Recruiting

Study contacts

• Study coordinator: Lars Vedel Kessing, professor, MD, DMSc.
• Email: lars.vedel.kessing@regionh.dk
• Phone: +45 38 64 70 81

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.