Comparing Lidocaine and Ketamine for Pain Management in Colorectal Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of intravenous Lidocaine versus intravenous Ketamine in managing pain for patients undergoing open colorectal surgery. Participants are randomly assigned to receive either a loading dose followed by a continuous infusion of Lidocaine or Ketamine over a 24-hour period. The study measures plasma concentrations of Interleukin-6 (IL-6) before and after surgery to assess the inflammatory response associated with each treatment. The goal is to determine which medication is more effective in reducing postoperative inflammation and pain.

Why it matters

Who can join: the full rules

INCLUSION CRITERIA:

* Patients aged 18 or older.
* American society of anesthesiologists' (ASA) physical status of I-III.
* Elective open colorectal surgery.

NON INCLUSION CRITERIA:

* Patients with contraindications to lidocaine or ketamine.
* Corticosteroid therapy within the last 6 months.
* History of immunosuppressive therapy.
* History of surgery in the last 3 months.
* Personal medical history of inflammatory bowel disease.
* Personal medical history of cardiac arrythmias or conduction disorders.
* Alcohol or drug abuse.
* Chronic use of opioids or benzodiazepines.

EXCLUSION CRITERIA:

* Severe intraoperative complications.
* Duration of surgery longer than 5 hours.

Where it's running

• Tunisia
  Nabeul, Tunisia Recruiting

Study contacts

• Principal investigator: BEN ALI MECHAAL, Professor — university manar Tunis, Tunisia
• Study coordinator: BEN ALI MECHAAL, Professor
• Email: mechaal_benali@yahoo.fr
• Phone: 72100533

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.