Comparing Lidocaine and Ketamine for Pain Management in Colorectal Surgery
The Effect of Intravenous Lidocaine or Ketamine on Interleukin-6 Levels in Patients Undergoing Colorectal Surgery for Cancer: A Randomized Controlled Trial
NA · University Tunis El Manar · NCT06272461
This study is testing whether intravenous Lidocaine or Ketamine works better for managing pain and reducing inflammation in patients having open colorectal surgery.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 18 Years to 90 Years |
| Sex | All |
| Sponsor | University Tunis El Manar (other) |
| Locations | 1 site (Nabeul) |
| Trial ID | NCT06272461 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effectiveness of intravenous Lidocaine versus intravenous Ketamine in managing pain for patients undergoing open colorectal surgery. Participants are randomly assigned to receive either a loading dose followed by a continuous infusion of Lidocaine or Ketamine over a 24-hour period. The study measures plasma concentrations of Interleukin-6 (IL-6) before and after surgery to assess the inflammatory response associated with each treatment. The goal is to determine which medication is more effective in reducing postoperative inflammation and pain.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 or older who are scheduled for elective open colorectal surgery and have an ASA physical status of I-III.
Not a fit: Patients with contraindications to lidocaine or ketamine, or those with a history of certain medical conditions or recent surgeries, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved pain management strategies for patients undergoing colorectal surgery.
How similar studies have performed: Other studies have shown promising results with similar approaches using intravenous anesthetics for pain management, suggesting potential for success in this trial.
Eligibility criteria
Show full inclusion / exclusion criteria
INCLUSION CRITERIA: * Patients aged 18 or older. * American society of anesthesiologists' (ASA) physical status of I-III. * Elective open colorectal surgery. NON INCLUSION CRITERIA: * Patients with contraindications to lidocaine or ketamine. * Corticosteroid therapy within the last 6 months. * History of immunosuppressive therapy. * History of surgery in the last 3 months. * Personal medical history of inflammatory bowel disease. * Personal medical history of cardiac arrythmias or conduction disorders. * Alcohol or drug abuse. * Chronic use of opioids or benzodiazepines. EXCLUSION CRITERIA: * Severe intraoperative complications. * Duration of surgery longer than 5 hours.
Where this trial is running
Nabeul
- Tunisia — Nabeul, Tunisia (RECRUITING)
Study contacts
- Principal investigator: BEN ALI MECHAAL, Professor — university manar Tunis, Tunisia
- Study coordinator: BEN ALI MECHAAL, Professor
- Email: mechaal_benali@yahoo.fr
- Phone: 72100533
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Colorectal Cancer, Inflammation