Comparing Labetalol and Dexmedetomidine for Lowering Blood Pressure During Surgery
Comparative Study of Labetalol Infusion Versus Dexmedetomidine Infusion in Hypotensive Anesthesia in Ear, Nose and Throat Surgeries
This study is testing whether Labetalol or Dexmedetomidine works better to lower blood pressure during ear, nose, and throat surgeries to help improve the surgery conditions.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 20 Years to 50 Years |
| Sex | All |
| Sponsor | Ain Shams University Academic / other |
| Locations | 1 site (Cairo, Cairo Governorate) |
| Trial ID | NCT06752863 on ClinicalTrials.gov |
What this trial studies
This study compares the effectiveness of Labetalol infusion versus Dexmedetomidine infusion in achieving hypotensive anesthesia during ear, nose, and throat surgeries. Hypotensive anesthesia involves intentionally lowering a patient's blood pressure to improve surgical conditions, such as reducing bleeding and facilitating the procedure. Labetalol acts as an anti-hypertensive agent with both alpha and beta-blocking properties, while Dexmedetomidine is an alpha-2 adrenergic agonist that promotes hypotension and bradycardia. The study aims to determine which of these two medications is more effective in this specific surgical context.
Who should consider this trial
Good fit: Ideal candidates are healthy adults aged 20 to 50 with ASA I or II classification who are scheduled for ear, nose, and throat surgeries.
Not a fit: Patients with uncontrolled hypertension, heart block, or other significant health issues, as well as pregnant or lactating women, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance surgical outcomes and patient safety by optimizing blood pressure management during ear, nose, and throat procedures.
How similar studies have performed: Previous studies have shown promising results with both Labetalol and Dexmedetomidine in similar contexts, indicating that this approach is supported by existing evidence.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * American Society of Anesthesiologists I, II (ASA I, II) patients who were candidate for Ear, Nose and Throat surgeries. * Age: between 20 and 50 years Exclusion Criteria: * Patients with uncontrolled hypertension, variable degrees of heart block, congestive cardiac failure, coagulopathy, cerebral insufficiency, hepatic or renal abnormality * Patients on beta blocker or clonidine * Pregnant or lactating females * Patients who were allergic to any of the anesthetic or hypotensive drugs used in the study * Patient refusal to be included in the trial
Where this trial is running
Cairo, Cairo Governorate
- Ain Shams university — Cairo, Cairo Governorate, Egypt (Recruiting)
Study contacts
- Study coordinator: Nourhan Osama, Master degree
- Email: NourhanosamaMohamed@med.asu.edu.eg
- Phone: 002 01064764758
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.