Comparing ketamine and magnesium sulfate for faster awakening after anesthesia
Ketamine Versus Magnesium Sulfate in the Time and Awakening Quality of General Anesthesia. Randomized Clinical Study.
This study is testing whether ketamine or magnesium sulfate can help people wake up faster and feel better after surgery to remove the gallbladder.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 140 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | University of Sao Paulo General Hospital Academic / other |
| Locations | 1 site (Santos, São Paulo) |
| Trial ID | NCT04360473 on ClinicalTrials.gov |
What this trial studies
This trial aims to evaluate the effects of ketamine and magnesium sulfate on the quality and time of awakening in patients undergoing laparoscopic cholecystectomy. Participants will be divided into four groups, receiving either a placebo, ketamine, magnesium sulfate, or a combination of both prior to anesthesia. The primary outcomes include the time taken to reach a specific level of consciousness and cognitive function assessed three hours post-anesthesia. Secondary outcomes will focus on pain management and opioid consumption during the initial postoperative period.
Who should consider this trial
Good fit: Ideal candidates are patients scheduled for laparoscopic cholecystectomy who can provide informed consent.
Not a fit: Patients with coronary disease, severe obesity, or a history of psychiatric disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved recovery times and enhanced patient satisfaction following laparoscopic cholecystectomy.
How similar studies have performed: Previous studies have shown promising results with similar approaches using ketamine and magnesium sulfate for postoperative pain management.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * patients scheduled to undergo laparoscopic cholecystectomy, agreement to voluntarily participate in the trial and sign the free and informed consent form. Exclusion Criteria: * Coronary disease, ventricular atrial block II or worse, with renal failure , previous history of brain disease, dementia or other psychiatric diseases, and patients with a body mass index\> 35 kg / m² , allergy to any products used in the trial, preoperative use of opioids or corticosteroids.
Where this trial is running
Santos, São Paulo
- Hospital da Beneficência Portuguesa de Santos — Santos, São Paulo, Brazil (Recruiting)
Study contacts
- Principal investigator: Joaquim Vieira — University of Sao Paulo School of Medicine
- Study coordinator: sebastião ernesto
- Email: sebasernesto@gmail.com
- Phone: 12991457764
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.